A base-promoted synthesis of 3,4-dihydro-2(1H)-quinazolinones

Rui Xiong, Yadi Liu, Fang-Lin Zhang
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Abstract

A convenient and concise base-promoted synthesis of 3,4-dihydro-2(1H)-quinazolinones and multi-membered cyclic ureas has been developed. In the presence of tBuOK, a variety of 3,4-dihydro-2(1H)-quinazolinones as well as the N-arylated five-, six- and nine-membered cyclic ureas were readily synthesized under mild conditions. This method offers an alternative synthesis toolkit towards cyclic ureas.
3,4-二氢-2(1H)-喹唑啉酮的碱促进合成法
我们开发出了一种方便简捷的碱促进合成 3,4-二氢-2(1H)-喹唑啉酮和多元环状脲的方法。在 tBuOK 的存在下,各种 3,4-二氢-2(1H)-喹唑啉酮以及 N-芳基化的五元、六元和九元环状脲类化合物在温和的条件下很容易合成。这种方法为环状脲类化合物提供了另一种合成工具包。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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