Novel NIR-II 3,5-Julolidinyl aza-BODIPY for Photothermal Therapy of Gliomas Stem Cells by Brain Stereotactic Injection

IF 11.3 1区化学 Q1 CHEMISTRY, PHYSICAL

ACS Catalysis Pub Date : 2024-09-20 DOI:10.1021/acsmaterialslett.4c01447

Lulu Cao, Zhiqiang Cui, Dongxiang Zhang, Yikun Li, Xiaoyan Gao, Rong Shang, Xin-Dong Jiang, Jianjun Du, Xiaohong Sun

引用次数: 0

Abstract

Functional dyes with absorption in the second near-infrared window (NIR-II) show great promise in photothermal therapy. Herein, the novel NIR-II 3,5-julolidinyl aza-BODIPY (JLD) was prepared and confirmed by X-ray crystallographic analysis for the first time. The molecular packing structure facilitates the J-aggregation packing mode. Self-assembled JLD-nanoparticles (JLD-NPs) emit fluorescence (λ_em = 962 nm, Φ_f = 0.1%), and a peak belt covered a NIR-II range of 900–1300 nm. The photothermal conversion efficiency was high and was calculated to be 79%. JLD-NPs with NIR-II 915 nm laser irradiation had the good tumor-inhibition capability with promoting the apoptosis and inhibiting the stemness of glioblastoma cells by brain stereotactic injection and affect the occurrence of malignant events, such as migration and invasion.

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通过脑立体定向注射对胶质瘤干细胞进行光热治疗的新型 NIR-II 3,5-Julolidinyl aza-BODIPY

在第二个近红外窗口（NIR-II）具有吸收功能的功能性染料在光热疗法中大有可为。本文制备了新型 NIR-II 3,5-julolidinyl aza-BODIPY (JLD)，并首次通过 X 射线晶体分析进行了确认。其分子堆积结构有利于 J 聚集堆积模式。自组装的JLD-纳米粒子（JLD-NPs）发出荧光（λem = 962 nm, Φf = 0.1%），峰带覆盖900-1300 nm的近红外-II波段。光热转换效率很高，经计算为 79%。JLD-NPs 在近红外-II波段915 nm激光照射下具有良好的肿瘤抑制能力，通过脑立体定向注射促进胶质母细胞瘤细胞凋亡和抑制干细胞，影响迁移和侵袭等恶性事件的发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Catalysis CHEMISTRY, PHYSICAL-

CiteScore

20.80

自引率

6.20%

发文量

1253

审稿时长

1.5 months

期刊介绍： ACS Catalysis is an esteemed journal that publishes original research in the fields of heterogeneous catalysis, molecular catalysis, and biocatalysis. It offers broad coverage across diverse areas such as life sciences, organometallics and synthesis, photochemistry and electrochemistry, drug discovery and synthesis, materials science, environmental protection, polymer discovery and synthesis, and energy and fuels. The scope of the journal is to showcase innovative work in various aspects of catalysis. This includes new reactions and novel synthetic approaches utilizing known catalysts, the discovery or modification of new catalysts, elucidation of catalytic mechanisms through cutting-edge investigations, practical enhancements of existing processes, as well as conceptual advances in the field. Contributions to ACS Catalysis can encompass both experimental and theoretical research focused on catalytic molecules, macromolecules, and materials that exhibit catalytic turnover.