Diagnostic potential of combining plasma biomarkers of tissue damage and inflammation in pediatric TB

IF 4.5 2区医学 Q2 IMMUNOLOGY

Journal of Microbiology Immunology and Infection Pub Date : 2024-09-06 DOI:10.1016/j.jmii.2024.07.011

Andrea López-Suárez, Mar Santos-Sebastián, Alicia Hernanz-Lobo, Elena Rincón-López, David Aguilera-Alonso, Jesús Saavedra-Lozano, María Jesús Ruiz Serrano, Ángel Hernández-Bartolomé, Luz María Medrano de Dios, José Luis Jiménez Fuentes, María Luisa Navarro, Marc Tebruegge, Begoña Santiago-García

引用次数: 0

Abstract

Immune-based diagnostic tests for tuberculosis (TB) have suboptimal sensitivity in children and cannot differentiate between latent infection (LTBI) and active disease. This study evaluated the diagnostic potential of a broad range of biomarkers of tissue damage and inflammation in unstimulated plasma in children.

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结合小儿肺结核组织损伤和炎症的血浆生物标志物的诊断潜力

基于免疫的结核病诊断测试对儿童的灵敏度不够理想，而且无法区分潜伏感染（LTBI）和活动性疾病。这项研究评估了儿童非刺激血浆中多种组织损伤和炎症生物标志物的诊断潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Microbiology Immunology and Infection IMMUNOLOGY-INFECTIOUS DISEASES

CiteScore

15.90

自引率

5.40%

发文量

159

审稿时长

67 days

期刊介绍： Journal of Microbiology Immunology and Infection is an open access journal, committed to disseminating information on the latest trends and advances in microbiology, immunology, infectious diseases and parasitology. Article types considered include perspectives, review articles, original articles, brief reports and correspondence. With the aim of promoting effective and accurate scientific information, an expert panel of referees constitutes the backbone of the peer-review process in evaluating the quality and content of manuscripts submitted for publication.