Systematic analysis of Fc mutations designed to reduce binding to Fc-gamma receptors

IF 5.6 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

mAbs Pub Date : 2024-09-15 DOI:10.1080/19420862.2024.2402701

Geoff Hale, Jelle De Vos, Alastair Douglas Davy, Koen Sandra, Ian Wilkinson

引用次数: 0

Abstract

Elimination of the binding of immunoglobulin Fc to Fc gamma receptors is highly desirable for the avoidance of unwanted inflammatory responses to therapeutic antibodies and fusion proteins. Many di...

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对旨在减少与 Fc-gamma 受体结合的 Fc 突变的系统分析

消除免疫球蛋白 Fc 与 Fc γ 受体的结合对于避免治疗性抗体和融合蛋白引起不必要的炎症反应是非常理想的。许多二...

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来源期刊

mAbs 工程技术-仪器仪表

CiteScore

10.70

自引率

11.30%

发文量

审稿时长

6-12 weeks

期刊介绍： mAbs is a multi-disciplinary journal dedicated to the art and science of antibody research and development. The journal has a strong scientific and medical focus, but also strives to serve a broader readership. The articles are thus of interest to scientists, clinical researchers, and physicians, as well as the wider mAb community, including our readers involved in technology transfer, legal issues, investment, strategic planning and the regulation of therapeutics.