Food antigens suppress small intestinal tumorigenesis

IF 5.7 2区医学 Q1 IMMUNOLOGY

Frontiers in Immunology Pub Date : 2024-09-18 DOI:10.3389/fimmu.2024.1373766

Takaharu Sasaki, Yuna Ota, Yui Takikawa, Tommy Terrooatea, Takashi Kanaya, Masumi Takahashi, Naoko Taguchi-Atarashi, Naoko Tachibana, Haruka Yabukami, Charles D. Surh, Aki Minoda, Kwang Soon Kim, Hiroshi Ohno

{"title":"Food antigens suppress small intestinal tumorigenesis","authors":"Takaharu Sasaki, Yuna Ota, Yui Takikawa, Tommy Terrooatea, Takashi Kanaya, Masumi Takahashi, Naoko Taguchi-Atarashi, Naoko Tachibana, Haruka Yabukami, Charles D. Surh, Aki Minoda, Kwang Soon Kim, Hiroshi Ohno","doi":"10.3389/fimmu.2024.1373766","DOIUrl":null,"url":null,"abstract":"Food components suppressing small intestinal tumorigenesis are not well-defined partly because of the rarity of this tumor type compared to colorectal tumors. Using Apcmin/+ mice, a mouse model for intestinal tumorigenesis, and antigen-free diet, we report here that food antigens serve this function in the small intestine. By depleting Peyer’s patches (PPs), immune inductive sites in the small intestine, we found that PPs have a role in the suppression of small intestinal tumors and are important for the induction of small intestinal T cells by food antigens. On the follicle-associated epithelium (FAE) of PPs, microfold (M) cells pass food antigens from lumen to the dendritic cells to induce T cells. Single-cell RNA-seq (scRNA-seq) analysis of immune cells in PPs revealed a significant impact of food antigens on the induction of the PP T cells and the antigen presentation capacity of dendritic cells. These data demonstrate the role of food antigens in the suppression of small intestinal tumorigenesis by PP-mediated immune cell induction.","PeriodicalId":12622,"journal":{"name":"Frontiers in Immunology","volume":null,"pages":null},"PeriodicalIF":5.7000,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Immunology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fimmu.2024.1373766","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Food components suppressing small intestinal tumorigenesis are not well-defined partly because of the rarity of this tumor type compared to colorectal tumors. Using Apcmin/+ mice, a mouse model for intestinal tumorigenesis, and antigen-free diet, we report here that food antigens serve this function in the small intestine. By depleting Peyer’s patches (PPs), immune inductive sites in the small intestine, we found that PPs have a role in the suppression of small intestinal tumors and are important for the induction of small intestinal T cells by food antigens. On the follicle-associated epithelium (FAE) of PPs, microfold (M) cells pass food antigens from lumen to the dendritic cells to induce T cells. Single-cell RNA-seq (scRNA-seq) analysis of immune cells in PPs revealed a significant impact of food antigens on the induction of the PP T cells and the antigen presentation capacity of dendritic cells. These data demonstrate the role of food antigens in the suppression of small intestinal tumorigenesis by PP-mediated immune cell induction.

查看原文本刊更多论文

食物抗原抑制小肠肿瘤发生

抑制小肠肿瘤发生的食物成分尚未得到很好的界定，部分原因是与结肠直肠肿瘤相比，这种肿瘤类型很少见。我们利用Apcmin/+小鼠（一种肠道肿瘤发生的小鼠模型）和无抗原饮食，在此报告了食物抗原在小肠中的这种功能。通过消耗小肠中的免疫诱导位点佩耶氏斑块（Peyer's patches，PPs），我们发现PPs在抑制小肠肿瘤中发挥作用，并且对食物抗原诱导小肠T细胞很重要。在PPs的滤泡相关上皮（FAE）上，微褶（M）细胞将食物抗原从管腔传递到树突状细胞，从而诱导T细胞。对PP免疫细胞的单细胞RNA-seq（scRNA-seq）分析表明，食物抗原对PP T细胞的诱导和树突状细胞的抗原递呈能力有显著影响。这些数据证明了食物抗原在通过PP介导的免疫细胞诱导抑制小肠肿瘤发生中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Frontiers in Immunology IMMUNOLOGY-

CiteScore

9.80

自引率

11.00%

发文量

7153

审稿时长

14 weeks

期刊介绍： Frontiers in Immunology is a leading journal in its field, publishing rigorously peer-reviewed research across basic, translational and clinical immunology. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Immunology is the official Journal of the International Union of Immunological Societies (IUIS). Encompassing the entire field of Immunology, this journal welcomes papers that investigate basic mechanisms of immune system development and function, with a particular emphasis given to the description of the clinical and immunological phenotype of human immune disorders, and on the definition of their molecular basis.