Polyoxometalates and their composites for antimicrobial applications: Advances, mechanisms and future prospects

Abstract

The overuse of antibiotics can lead to the development of antibiotic-resistant bacteria, which can be even more difficult to treat and pose an even greater threat to public health. In order to address the issue of antibiotic-resistant bacteria, researchers currently are exploring alternative methods of sterilization that are both effective and sustainable. Polyoxometalates (POMs), as emerging transition metal oxide compounds, exhibit significant potential in various applications due to their remarkable tunable physical and chemical performance, especially in antibacterial fields. They constitute a diverse family of inorganic clusters, characterized by a wide array of composition, structures and charges. Presently, several studies indicated that POM-based composites have garnered extensive attention in the realms of the antibacterial field and may become promising materials for future medical applications. Moreover, this review will focus on exploring the antibacterial properties and mechanisms of different kinds of organic-inorganic hybrid POMs, POM-based composites, films and hydrogels with substantial bioactivity, while POM-based composites have the dual advantages of POMs and other materials. Additionally, the potential antimicrobial mechanisms have also been discussed, mainly encompassing cell wall/membrane disruption, intracellular material leakage, heightened intracellular reactive oxygen species (ROS) levels, and depletion of glutathione (GSH). These findings open up exciting possibilities for POMs as exemplary materials in the antibacterial arena and expand their prospective applications.