Evaluating the role of biological age in osteoporosis risk among middle-aged and older adults: A nationwide perspective

IF 3.5 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Bone Pub Date : 2024-09-14 DOI:10.1016/j.bone.2024.117255

Guomao Zhu , Buyu Guo , Jinqian Liang

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引用次数: 0

Abstract

Objectives

This study aimed to investigate the association between biological age acceleration and osteoporosis (OP) risk in middle-aged and older adults using data from the National Health and Nutrition Examination Survey (NHANES). The research focused on analyzing the relationship between two biological aging metrics, Klemera-Doubal Method Age (KDMAge) and Phenotypic Age (PhenoAge), and OP risk.

Methods

The study analyzed data from NHANES, which included 6550 participants aged 50 and above from survey cycles 2005–2010 and 2017–2018. Linear and logistic regression were used to investigate the relationship between biological age acceleration (KDMAgeAccel and PhenoAgeAccel) and OP. Subgroup analysis was performed by age, gender and other factors. Multivariable Cox regression analysis yielded Hazard Ratios (HRs) relating biological age acceleration to mortality were evaluated. The study also considered the mediating roles of body mass index (BMI).

Results

KDMAgeAccel (odds ratio [OR] = 2.34, 95 % CI, 1.72–3.18) and PhenoAgeAccel (OR = 2.03, 95 % CI, 1.48–2.78) were significantly associated with increased OP risk and reduced bone mineral density (BMD). Specifically, higher KDMAgeAccel and PhenoAgeAccel were linked to higher OP prevalence and lower BMD at multiple sites. Subgroup analyses indicated that the association between accelerated biological age acceleration and OP risk was consistent across different demographics. Mediation analysis revealed that BMI partially mediated the relationship between accelerated biological age and OP, although other mechanisms are likely involved. Statistical analysis indicated that individuals with higher biological age metrics had increased mortality risk related to OP.

Conclusion

The findings suggest that accelerated biological age is a robust predictor of OP risk and related mortality. KDMAgeAccel and PhenoAgeAccel could serve as valuable biomarkers for identifying individuals at high risk for OP, guiding preventive strategies.

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评估生理年龄在中老年人骨质疏松症风险中的作用：全国视角

目的本研究旨在利用美国国家健康与营养调查（NHANES）的数据，调查中老年人的生物年龄加速度与骨质疏松症（OP）风险之间的关系。研究重点分析了克莱默拉-杜巴法年龄（KDMAge）和表型年龄（Phenotypic Age，PhenoAge）这两个生物衰老指标与OP风险之间的关系。研究分析了NHANES的数据，其中包括2005-2010年和2017-2018年调查周期中6550名50岁及以上的参与者。研究采用线性回归和逻辑回归来探讨生物年龄加速度（KDMAgeAccel 和 PhenoAgeAccel）与 OP 之间的关系。根据年龄、性别和其他因素进行了分组分析。通过多变量考克斯回归分析，评估了生物年龄加速与死亡率之间的危险比（HRs）。研究还考虑了体重指数（BMI）的中介作用。结果KDMAgeAccel（比值比 [OR] = 2.34，95 % CI，1.72-3.18）和 PhenoAgeAccel（比值比 = 2.03，95 % CI，1.48-2.78）与 OP 风险增加和骨矿密度（BMD）降低显著相关。具体来说，较高的 KDMAgeAccel 和 PhenoAgeAccel 与 OP 患病率较高和多个部位的 BMD 较低有关。亚组分析表明，生物年龄加速与 OP 风险之间的关系在不同人口统计学中是一致的。中介分析显示，体重指数（BMI）在一定程度上中介了生物年龄加速与 OP 之间的关系，但也可能涉及其他机制。统计分析表明，生物年龄指标较高的个体与 OP 相关的死亡风险增加。KDMAgeAccel和PhenoAgeAccel可作为识别OP高风险人群的重要生物标记物，为预防策略提供指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bone 医学-内分泌学与代谢

CiteScore

8.90

自引率

4.90%

发文量

264

审稿时长

30 days

期刊介绍： BONE is an interdisciplinary forum for the rapid publication of original articles and reviews on basic, translational, and clinical aspects of bone and mineral metabolism. The Journal also encourages submissions related to interactions of bone with other organ systems, including cartilage, endocrine, muscle, fat, neural, vascular, gastrointestinal, hematopoietic, and immune systems. Particular attention is placed on the application of experimental studies to clinical practice.