Ticagrelor-related dyspnea beyond adenosine: Insights into retrotrapezoid hyperactivity

IF 1.9 4区医学 Q3 PHYSIOLOGY

Respiratory Physiology & Neurobiology Pub Date : 2024-09-16 DOI:10.1016/j.resp.2024.104349

Enver Ahmet Demir, Okan Gonder

引用次数: 0

Abstract

Ticagrelor, a P2Y₁₂ receptor antagonist, has been demonstrated to induce dyspnea, which is not associated with cardiac or pulmonary alterations, or metabolic disturbances. The attribution of ticagrelor-related dyspnea to excess adenosine has been widely proposed, yet is not supported by experimental data. In this paper, we put forth a novel hypothesis that the hyperactivity of the retrotrapezoid nucleus, a group of ventral medullary neurons involved in respiratory modulation, is the underlying cause of ticagrelor-related dyspnea. This hypothesis offers a theoretical resolution to the discrepancies and controversies present in previous theories.

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超越腺苷的替卡格雷相关呼吸困难：后蛛网膜活动亢进的启示

P2Y12 受体拮抗剂替卡格雷已被证实可诱发呼吸困难，但与心肺功能改变或代谢紊乱无关。人们普遍认为，与替卡格雷相关的呼吸困难是由于过量腺苷引起的，但这一观点并未得到实验数据的支持。在本文中，我们提出了一个新的假设，即参与呼吸调节的腹侧延髓神经元组--后蛛网膜核的过度活跃是导致替卡格雷相关性呼吸困难的根本原因。这一假说从理论上解决了以往理论中存在的差异和争议。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Respiratory Physiology & Neurobiology 医学-呼吸系统

CiteScore

4.80

自引率

8.70%

发文量

104

审稿时长

54 days

期刊介绍： Respiratory Physiology & Neurobiology (RESPNB) publishes original articles and invited reviews concerning physiology and pathophysiology of respiration in its broadest sense. Although a special focus is on topics in neurobiology, high quality papers in respiratory molecular and cellular biology are also welcome, as are high-quality papers in traditional areas, such as: -Mechanics of breathing- Gas exchange and acid-base balance- Respiration at rest and exercise- Respiration in unusual conditions, like high or low pressure or changes of temperature, low ambient oxygen- Embryonic and adult respiration- Comparative respiratory physiology. Papers on clinical aspects, original methods, as well as theoretical papers are also considered as long as they foster the understanding of respiratory physiology and pathophysiology.