Ticagrelor-related dyspnea beyond adenosine: Insights into retrotrapezoid hyperactivity

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-09-16 DOI:10.1016/j.resp.2024.104349

Enver Ahmet Demir, Okan Gonder

引用次数: 0

Abstract

Ticagrelor, a P2Y₁₂ receptor antagonist, has been demonstrated to induce dyspnea, which is not associated with cardiac or pulmonary alterations, or metabolic disturbances. The attribution of ticagrelor-related dyspnea to excess adenosine has been widely proposed, yet is not supported by experimental data. In this paper, we put forth a novel hypothesis that the hyperactivity of the retrotrapezoid nucleus, a group of ventral medullary neurons involved in respiratory modulation, is the underlying cause of ticagrelor-related dyspnea. This hypothesis offers a theoretical resolution to the discrepancies and controversies present in previous theories.

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超越腺苷的替卡格雷相关呼吸困难：后蛛网膜活动亢进的启示

P2Y12 受体拮抗剂替卡格雷已被证实可诱发呼吸困难，但与心肺功能改变或代谢紊乱无关。人们普遍认为，与替卡格雷相关的呼吸困难是由于过量腺苷引起的，但这一观点并未得到实验数据的支持。在本文中，我们提出了一个新的假设，即参与呼吸调节的腹侧延髓神经元组--后蛛网膜核的过度活跃是导致替卡格雷相关性呼吸困难的根本原因。这一假说从理论上解决了以往理论中存在的差异和争议。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.