Catalyst-Free C-H Methylation of Heteroarenes Enabled by Electron Donor-Acceptor Complex Photoactivation

IF 4.6 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2024-09-18 DOI:10.1039/d4qo01309c

Jiayang Wang, baoer shao, Hai Xia Ge, Huiyu Xue, Xiangyuan Ding, Yuqi Li, Peiyao Sheng

引用次数: 0

Abstract

An efficient, additive- and catalyst -free, visible-light-driven radical C-H methylation of heteroarenes (including quinoxalinones, pyrazinones, quinolinones and coumarins) utilizing readily available methylamines as the methyl source has been developed. The transformation possesses the advantages of operational simplicity, mild reaction conditions and broad substrate scope. Mechanistic studies disclosed that a photoactive electron donor-acceptor (EDA) complex between methylamines and heteroarenes is crucial to this transformation.

查看原文本刊更多论文

电子供体-受体复合物光活化催化杂环烯的无催化剂 C-H 甲基化反应

我们开发了一种高效、无添加剂和催化剂、可见光驱动的杂环戊烯（包括喹喔啉酮类、吡嗪酮类、喹啉酮类和香豆素类）自由基 C-H 甲基化反应，利用现成的甲基胺作为甲基源。这种转化方法具有操作简单、反应条件温和、底物范围广等优点。机理研究表明，甲胺和杂环戊烯之间的光活性电子供体-受体（EDA）复合物对这一转化至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.