A model for a dual function of N6-methyladenosine in R-loop regulation

IF 31.7 1区生物学 Q1 GENETICS & HEREDITY

Nature genetics Pub Date : 2024-09-17 DOI:10.1038/s41588-024-01905-5

Abdulkadir Abakir, Alexey Ruzov

引用次数: 0

Abstract

R-loops contain DNA:RNA hybrids and an unpaired single-stranded DNA. N6-methyladenosine (m6A) has been reported to modulate R-loop levels, but with varying outcomes (R-loop resolution versus stabilization). We propose that in different contexts, m6A may either directly prevent R-loop accumulation or stabilize R-loops via the formation of RNA abasic sites.

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N6-甲基腺苷在 R 环调控中的双重功能模型

R 环包含 DNA:RNA 杂交体和未配对的单链 DNA。据报道，N6-甲基腺苷（m6A）可调节 R 环水平，但结果各不相同（R 环解析与稳定）。我们认为，在不同的情况下，m6A 可直接阻止 R 环的积累，或通过形成 RNA 终止位点来稳定 R 环。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature genetics 生物-遗传学

CiteScore

43.00

自引率

2.60%

发文量

241

审稿时长

3 months

期刊介绍： Nature Genetics publishes the very highest quality research in genetics. It encompasses genetic and functional genomic studies on human and plant traits and on other model organisms. Current emphasis is on the genetic basis for common and complex diseases and on the functional mechanism, architecture and evolution of gene networks, studied by experimental perturbation. Integrative genetic topics comprise, but are not limited to: -Genes in the pathology of human disease -Molecular analysis of simple and complex genetic traits -Cancer genetics -Agricultural genomics -Developmental genetics -Regulatory variation in gene expression -Strategies and technologies for extracting function from genomic data -Pharmacological genomics -Genome evolution