Muhammad Babar Khawar , Ali Afzal , Sadia Ahmad , Yue Si , Shaaf Ahmad , Haibo Sun
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引用次数: 0
Abstract
Lipid droplets (LDs) accumulation in cancer cells has garnered attention due to their role in tumor progression. Cholesterol supports not only the biosynthesis of new membranes and cancer-associated signaling but also modulate tumor cell energy supply which makes it therapeutically promising to target cholesterol metabolism. We hypothesize that autophagy-modulated inhibition of cholesterol uptake will reduce LDs formation and impair tumor progression via a novel pathway. The proposed approach has promise in disrupting cancer cell progression via impairing autophagy-mediated cholesterol uptake and few other metabolic processes. We emphasize investigating these mechanisms as they could significantly advance cancer therapy via targeting cholesterol metabolism and autophagy.
期刊介绍：
Medical Hypotheses is a forum for ideas in medicine and related biomedical sciences. It will publish interesting and important theoretical papers that foster the diversity and debate upon which the scientific process thrives. The Aims and Scope of Medical Hypotheses are no different now from what was proposed by the founder of the journal, the late Dr David Horrobin. In his introduction to the first issue of the Journal, he asks ''what sorts of papers will be published in Medical Hypotheses? and goes on to answer ''Medical Hypotheses will publish papers which describe theories, ideas which have a great deal of observational support and some hypotheses where experimental support is yet fragmentary''. (Horrobin DF, 1975 Ideas in Biomedical Science: Reasons for the foundation of Medical Hypotheses. Medical Hypotheses Volume 1, Issue 1, January-February 1975, Pages 1-2.). Medical Hypotheses was therefore launched, and still exists today, to give novel, radical new ideas and speculations in medicine open-minded consideration, opening the field to radical hypotheses which would be rejected by most conventional journals. Papers in Medical Hypotheses take a standard scientific form in terms of style, structure and referencing. The journal therefore constitutes a bridge between cutting-edge theory and the mainstream of medical and scientific communication, which ideas must eventually enter if they are to be critiqued and tested against observations.
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