CAR T-cell therapy in cancer: Integrating nursing perspectives for enhanced patient care

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-08-23 DOI:10.1016/j.apjon.2024.100579

Ashna Gupta , Gunjan Dagar , Mohd Umar Rehmani , Chandra Prakash Prasad , Deepak Saini , Mayank Singh , Abhishek Shankar

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Abstract

Chimeric antigen receptor (CAR) T-cell therapy represents a significant advancement in cancer treatment, particularly for hematologic malignancies. Various cancer immunotherapy strategies are presently being explored, including cytokines, cancer vaccines, immune checkpoint inhibitors, immunomodulators monoclonal antibodies, etc. The therapy has shown impressive efficacy in treating conditions such as acute lymphoblastic leukemia (ALL), diffuse large B-cell lymphoma (DLBCL), and multiple myeloma, often leading to complete remission in refractory cases.

However, the clinical application of CAR T-cell therapy is accompanied by challenges, notably severe side effects. Effective management of these adverse effects requires meticulous monitoring and prompt intervention, highlighting the critical role of nursing in this therapeutic process.

Nurses play a crucial role in patient education, monitoring, symptom management, care coordination, and psychosocial support, ensuring safe and effective treatment. As research advances and new CAR T-cell therapies are developed, the role of nursing professionals remains pivotal in optimizing patient outcomes. The continued evolution of CAR T-cell therapy promises improved outcomes, with nursing professionals integral to its success.

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癌症 CAR T 细胞疗法：整合护理视角，加强患者护理

嵌合抗原受体（CAR）T 细胞疗法是癌症治疗领域的一大进步，尤其适用于血液系统恶性肿瘤。目前正在探索各种癌症免疫疗法策略，包括细胞因子、癌症疫苗、免疫检查点抑制剂、免疫调节剂单克隆抗体等。这种疗法在治疗急性淋巴细胞白血病（ALL）、弥漫性大 B 细胞淋巴瘤（DLBCL）和多发性骨髓瘤等疾病方面显示出令人印象深刻的疗效，往往能使难治性病例完全缓解。然而，CAR T 细胞疗法的临床应用也伴随着挑战，尤其是严重的副作用。护士在患者教育、监测、症状管理、护理协调和社会心理支持方面发挥着至关重要的作用，确保治疗安全有效。随着研究的进展和新 CAR T 细胞疗法的开发，护理专业人员在优化患者疗效方面仍起着至关重要的作用。CAR T 细胞疗法的不断发展有望改善疗效，而护理专业人员是其成功不可或缺的一部分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464