Pyroptosis of Breast Cancer Stem Cells and Immune Activation Enabled by a Multifunctional Prodrug Photosensitizer (Adv. Funct. Mater. 37/2024)

IF 18.5 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Functional Materials Pub Date : 2024-09-13 DOI:10.1002/adfm.202470217

Yuqi Tang, Zhichao Wang, Quan Li

引用次数: 0

Abstract

Breast Cancer Stem Cells

In article number 2405367, Quan Li, Yuqi Tang, and Zhichao Wang report a multifunctional prodrug photosensitizer that can reduce the tumorigenicity of breast cancer stem cells (CSCs) and overcome tumor resistance and recurrence. Importantly, this photosensitizer is found to be able to induce the pyroptosis of CSCs as well as to activate their death pathway protein phosphatase 2A to inhibit CSCs upon light activation, achieving synergistic cancer photoimmunotherapy.

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一种多功能原药光敏剂促进乳腺癌干细胞的猝灭和免疫激活（Adv. Funct. Mater. 37/2024）

乳腺癌干细胞在文章编号 2405367 中，李权、唐玉琪和王志超报告了一种多功能原药光敏剂，它能降低乳腺癌干细胞（CSCs）的致瘤性，克服肿瘤耐药性和复发性。重要的是，这种光敏剂不仅能诱导 CSCs 发生热休克，还能激活其死亡途径蛋白磷酸酶 2A，从而在光激活时抑制 CSCs，实现协同肿瘤光免疫治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Functional Materials 工程技术-材料科学：综合

CiteScore

29.50

自引率

4.20%

发文量

2086

审稿时长

2.1 months

期刊介绍： Firmly established as a top-tier materials science journal, Advanced Functional Materials reports breakthrough research in all aspects of materials science, including nanotechnology, chemistry, physics, and biology every week. Advanced Functional Materials is known for its rapid and fair peer review, quality content, and high impact, making it the first choice of the international materials science community.