Powerful microscopy technologies decode spatially organized cellular networks that drive response to immunotherapy in humans

IF 6.6 2区医学 Q1 IMMUNOLOGY

Current Opinion in Immunology Pub Date : 2024-09-14 DOI:10.1016/j.coi.2024.102463

Jonathan H Chen , Liad Elmelech , Alexander L Tang , Nir Hacohen

引用次数: 0

Abstract

In tumors, immune cells organize into networks of different sizes and composition, including complex tertiary lymphoid structures and recently identified networks centered around the chemokines CXCL9/10/11 and CCL19. New commercially available highly multiplexed microscopy using cyclical RNA in situ hybridization and antibody-based approaches have the potential to establish the organization of the immune response in human tissue and serve as a foundation for future immunology research.

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强大的显微镜技术解码了驱动人体免疫疗法反应的空间组织细胞网络

在肿瘤中，免疫细胞组织成不同大小和组成的网络，包括复杂的三级淋巴结构和最近发现的以趋化因子 CXCL9/10/11 和 CCL19 为中心的网络。使用循环 RNA 原位杂交和抗体方法的新型商用高复用显微镜有可能确定人体组织中免疫反应的组织结构，并为未来的免疫学研究奠定基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Immunology 医学-免疫学

CiteScore

13.30

自引率

1.40%

发文量

审稿时长

67 days

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