Ovarian cancer in the Arab world: An updated review

IF 1 Q4 GENETICS & HEREDITY

Gene Reports Pub Date : 2024-09-07 DOI:10.1016/j.genrep.2024.102025

Joseph Azar , Tala Kaddoura , Michael Anthony Timonian , Elsa Salim Karam , Wassim Abou-Kheir, Georges Daoud

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引用次数: 0

Abstract

Ovarian cancer is among the most commonly diagnosed cancer in women worldwide. Multiple risk factors could be attributed to the development of this disease, thus implicating variable incidence rates worldwide. Being the sixth in incidence and fourth in mortality among all cancers in women in the Arab world, ovarian cancer should be allocated a considerable interest among the other gynecologic cancers. This review aims to project the current epidemiological perspective in this part of the world while trying to consider several factors that could explain the incidence variability between the Arab countries internally, and externally compared to the world. The screening, prognostic factors and treatment modalities that are currently adopted in different Arab countries will be also presented. Close attention is additionally paid to the remarkable genetic difference that is found in the Arab countries pool, which could also be considered as a major factor that could explain the mentioned variability. In conclusion, noticeable efforts are seen in the Arab world when it comes to ovarian cancer-related research. However, further investigations for additional risk factors should be conducted to improve the early detection of this mostly asymptomatic disease and thereby enhance the quality of life and the disease prognosis.

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阿拉伯世界的卵巢癌：最新回顾

卵巢癌是全世界妇女最常诊断出的癌症之一。这种疾病的发生可能有多种风险因素，因此世界各地的发病率也不尽相同。卵巢癌在阿拉伯世界妇女所有癌症中发病率排第六位，死亡率排第四位，因此在其他妇科癌症中，卵巢癌应受到广泛关注。本综述旨在从流行病学的角度对世界上这一地区的卵巢癌现状进行预测，同时尝试考虑一些因素，以解释阿拉伯国家内部和外部与世界相比的发病率差异。此外，还将介绍不同阿拉伯国家目前采用的筛查、预后因素和治疗方式。此外，还将密切关注在阿拉伯国家人群中发现的显著遗传差异，这也可被视为解释上述差异的一个主要因素。总之，阿拉伯世界在卵巢癌相关研究方面做出了显著努力。不过，应进一步调查其他风险因素，以改善对这种大多无症状疾病的早期检测，从而提高生活质量和疾病预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gene Reports Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.30

自引率

7.70%

发文量

246

审稿时长

49 days

期刊介绍： Gene Reports publishes papers that focus on the regulation, expression, function and evolution of genes in all biological contexts, including all prokaryotic and eukaryotic organisms, as well as viruses. Gene Reports strives to be a very diverse journal and topics in all fields will be considered for publication. Although not limited to the following, some general topics include: DNA Organization, Replication & Evolution -Focus on genomic DNA (chromosomal organization, comparative genomics, DNA replication, DNA repair, mobile DNA, mitochondrial DNA, chloroplast DNA). Expression & Function - Focus on functional RNAs (microRNAs, tRNAs, rRNAs, mRNA splicing, alternative polyadenylation) Regulation - Focus on processes that mediate gene-read out (epigenetics, chromatin, histone code, transcription, translation, protein degradation). Cell Signaling - Focus on mechanisms that control information flow into the nucleus to control gene expression (kinase and phosphatase pathways controlled by extra-cellular ligands, Wnt, Notch, TGFbeta/BMPs, FGFs, IGFs etc.) Profiling of gene expression and genetic variation - Focus on high throughput approaches (e.g., DeepSeq, ChIP-Seq, Affymetrix microarrays, proteomics) that define gene regulatory circuitry, molecular pathways and protein/protein networks. Genetics - Focus on development in model organisms (e.g., mouse, frog, fruit fly, worm), human genetic variation, population genetics, as well as agricultural and veterinary genetics. Molecular Pathology & Regenerative Medicine - Focus on the deregulation of molecular processes in human diseases and mechanisms supporting regeneration of tissues through pluripotent or multipotent stem cells.