Sustained Ampicillin Loading and Releasing Ability of Novel In-Situ Ca2+ Functionalized Ternary GO/PVP/CMC Nanocomposite Hydrogel

IF 4.7 3区工程技术 Q2 ENGINEERING, ENVIRONMENTAL

Journal of Polymers and the Environment Pub Date : 2024-09-03 DOI:10.1007/s10924-024-03371-w

Almas Ishaque, Avadhesh Kumar, Mehtab Parveen, Nursabah Sarikavakli, Shahab A. A. Nami

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Abstract

A novel pH sensitive antibiotic carrier hydrogel was synthesized having sustained drug releasing capabilities. The in-situ polymerization of Graphene oxide (GO), Polyvinyl pyrrolidone (PVP), and Carboxymethyl cellulose (CMC) of varying stoichiometry having Ca²⁺ as a linker yielded ternary nanocomposite hydrogels GO/PVP/CMC-II and GO/PVP/CMC-III. The physicochemical, structural, morphological and swelling properties of the binary nanocomposite GO/PVP and ternary nanocomposite hydrogels, GO/PVP/CMC were investigated using FTIR, XRD, SEM, TEM, TGA and DTA. FTIR and XRD confirm successive formation of ternary hydrogels. The hydrogels swelling studies at various pH levels viz. 4.5, 7 and 9.2, show that the swelling ability can be proportionally correlated with CMC concentration. To ensure the efficacy of this innovative hydrogel drug release application, an in vitro Ampicillin loading and release efficiency experiment at pH 7.2 (close to blood pH 7.3–7.5) was performed. Ternary hydrogels GO/PVP/CMC-II and GO/PVP/CMC-III exhibited sustained drug loading and release kinetics (72 h).

Graphical Abstract

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新型原位 Ca2+ 功能化三元 GO/PVP/CMC 纳米复合水凝胶的持续氨苄西林负载和释放能力

一种新型 pH 值敏感的抗生素载体水凝胶被合成出来，它具有持续释放药物的能力。将氧化石墨烯（GO）、聚乙烯吡咯烷酮（PVP）和羧甲基纤维素（CMC）以 Ca2+ 作为连接剂，按不同的化学计量原位聚合，得到了三元纳米复合水凝胶 GO/PVP/CMC-II 和 GO/PVP/CMC-III。使用傅立叶变换红外光谱、X 射线衍射、扫描电镜、TEM、TGA 和 DTA 研究了二元纳米复合材料 GO/PVP 和三元纳米复合材料 GO/PVP/CMC 的物理化学、结构、形态和溶胀特性。傅立叶变换红外光谱和 X 射线衍射证实了三元水凝胶的连续形成。在不同 pH 值（即 4.5、7 和 9.2）下进行的水凝胶溶胀研究表明，溶胀能力与 CMC 浓度成正比。为了确保这种创新的水凝胶药物释放应用的有效性，在 pH 值为 7.2（接近血液 pH 值 7.3-7.5）时进行了体外氨苄西林负载和释放效率实验。GO/PVP/CMC-II 和 GO/PVP/CMC-III 三元水凝胶表现出持续的药物负载和释放动力学（72 小时）。

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来源期刊

Journal of Polymers and the Environment 工程技术-高分子科学

CiteScore

9.50

自引率

7.50%

发文量

297

审稿时长

9 months

期刊介绍： The Journal of Polymers and the Environment fills the need for an international forum in this diverse and rapidly expanding field. The journal serves a crucial role for the publication of information from a wide range of disciplines and is a central outlet for the publication of high-quality peer-reviewed original papers, review articles and short communications. The journal is intentionally interdisciplinary in regard to contributions and covers the following subjects - polymers, environmentally degradable polymers, and degradation pathways: biological, photochemical, oxidative and hydrolytic; new environmental materials: derived by chemical and biosynthetic routes; environmental blends and composites; developments in processing and reactive processing of environmental polymers; characterization of environmental materials: mechanical, physical, thermal, rheological, morphological, and others; recyclable polymers and plastics recycling environmental testing: in-laboratory simulations, outdoor exposures, and standardization of methodologies; environmental fate: end products and intermediates of biodegradation; microbiology and enzymology of polymer biodegradation; solid-waste management and public legislation specific to environmental polymers; and other related topics.