Mangiferin: An effective agent against human malignancies

IF 3.5 2区 农林科学 Q2 FOOD SCIENCE & TECHNOLOGY
Nimra Irshad, Hammad Naeem, Muhammad Shahbaz, Muhammad Imran, Ahmed Mujtaba, Muzzamal Hussain, Waleed Al Abdulmonem, Suliman A. Alsagaby, Tadesse Fenta Yehuala, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Ehab M. Mostafa, Samy Selim, Soad K. Al Jaouni
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引用次数: 0

Abstract

Mangiferin is a bioactive substance present in high concentration in mangoes and also in some other fruits. Owing to its potential as a chemopreventive and chemotherapeutic agent against several types of cancer, this unique, significant, and well-researched polyphenol has received a lot of attention recently. It possesses the ability to treat cancers, including rectal cancer, prostate cancer, ovarian cancer, leukemia, gastric cancer, liver cancer, chronic pancreatitis, and lung cancer. It can control/regulate multiple key signaling pathways, such as signal transducer and activator of transcription 3 (STAT3), second mitochondria-derived activator of caspases/direct inhibitor of apoptosis (IAP)-binding protein with low propidium iodide (pl) (Smac/DIABLO) nuclear factor kappa B (NF-κB), phosphatidylinositol 3 kinase/protein 3 kinase (PI3K/Akt), transforming growth factor beta/suppressor of mothers against decapentaplegic (TGF-β/SMAD), c-jun N-terminal kinase/p38 mitogen-activated protein kinase (JNK/p38-MAPK), and phosphor-I kappa B kinase (p-IκB), which are crucial to the development of cancers. By triggering apoptotic signals and halting the advancement of the cell cycle, it can also prevent some cancer cell types from proliferating and developing. It has been revealed that mangiferin targets a variety of adhesion molecules, cytokines, pro-inflammatory transcription factors, kinases, chemokines, growth factors, and cell-cycle proteins. By means of preventing the onset, advancement, and metastasis of cancer, these targets may mediate the chemopreventive and therapeutic effects of mangiferin. Mangiferin has confirmed potential benefits in lung, cervical, breast, brain, and prostate cancers as well as leukemia whether administered alone or in combination with recognized anticancer compounds. More clinical trials and research investigations are required to completely unleash the potential of mangiferin, which may lower the risk of cancer onset and act as a preventive and therapeutic alternative for a number of cancers.

Abstract Image

芒果苷:抗人类恶性肿瘤的有效药物
芒果苷是一种生物活性物质,在芒果和其他一些水果中含量很高。由于芒果苷具有对多种癌症进行化学预防和化学治疗的潜力,这种独特、重要且经过深入研究的多酚类化合物最近受到了广泛关注。它具有治疗癌症的能力,包括直肠癌、前列腺癌、卵巢癌、白血病、胃癌、肝癌、慢性胰腺炎和肺癌。它能控制/调节多种关键信号通路,如信号转导和转录激活因子 3(STAT3)、线粒体衍生的第二代 Caspases 激活因子/低碘化丙啶(pl)直接凋亡抑制因子(IAP)结合蛋白(Smac/DIABLO)、核因子卡巴 B(NF-κB)、它们对癌症的发展至关重要。通过触发凋亡信号和阻止细胞周期的进展,它还能阻止某些癌细胞类型的增殖和发展。研究发现,芒果苷能够靶向多种粘附分子、细胞因子、促炎转录因子、激酶、趋化因子、生长因子和细胞周期蛋白。通过防止癌症的发生、发展和转移,这些靶点可能介导了芒果苷的化学预防和治疗效果。芒果苷已被证实对肺癌、宫颈癌、乳腺癌、脑癌、前列腺癌以及白血病有潜在疗效,无论是单独使用还是与公认的抗癌化合物联合使用。要完全释放芒果苷的潜力,还需要进行更多的临床试验和研究调查,因为芒果苷可以降低癌症发病风险,并作为多种癌症的预防和治疗替代品。
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来源期刊
Food Science & Nutrition
Food Science & Nutrition Agricultural and Biological Sciences-Food Science
CiteScore
7.40
自引率
5.10%
发文量
434
审稿时长
24 weeks
期刊介绍: Food Science & Nutrition is the peer-reviewed journal for rapid dissemination of research in all areas of food science and nutrition. The Journal will consider submissions of quality papers describing the results of fundamental and applied research related to all aspects of human food and nutrition, as well as interdisciplinary research that spans these two fields.
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