Bhargav T. Nallapu, Kellen K. Petersen, Tianchen Qian, Idris Demirsoy, Elham Ghanbarian, Christos Davatzikos, Richard B. Lipton, Ali Ezzati, Alzheimer’s Disease Neuroimaging Initiative
{"title":"A Machine Learning Approach to Predict Cognitive Decline in Alzheimer’s Disease Clinical Trials","authors":"Bhargav T. Nallapu, Kellen K. Petersen, Tianchen Qian, Idris Demirsoy, Elham Ghanbarian, Christos Davatzikos, Richard B. Lipton, Ali Ezzati, Alzheimer’s Disease Neuroimaging Initiative","doi":"10.1101/2024.09.03.24312481","DOIUrl":null,"url":null,"abstract":"<strong>Background</strong> Of persons randomized to the placebo arm of Alzheimer’s Disease (AD) treatment trials, 40% do not show cognitive decline over 80 weeks of follow-up. Identifying and excluding these individuals from both arms of randomized clinical trials (RCTs) of AD has the potential to increase power to detect treatment effects.","PeriodicalId":501367,"journal":{"name":"medRxiv - Neurology","volume":"19 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv - Neurology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.09.03.24312481","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Background Of persons randomized to the placebo arm of Alzheimer’s Disease (AD) treatment trials, 40% do not show cognitive decline over 80 weeks of follow-up. Identifying and excluding these individuals from both arms of randomized clinical trials (RCTs) of AD has the potential to increase power to detect treatment effects.
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