Effects of intrauterine infusion of autologous platelet-rich plasma gel on endometrial thickness and outcomes of frozen-thawed embryo transfer in women with thin endometrium

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC
Xiufen Wang, Yangyang Wang, Jing Li, Yetao Han, Minling Wei, Aike Xu, Liaobing Xin
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Abstract

Purpose

The purpose of this study is to determine whether intrauterine infusion of autologous platelet-rich plasma (PRP) gel increases endometrial thickness (EMT) and improves the outcomes of frozen-thawed embryo transfer (FET) in women with thin endometrium.

Methods

This study included 111 women (aged 25–44 years) who had thin endometrium. All patients had at least one previous cycle canceled because of thin endometrium or previous embryo transfer cycles and an EMT < 7 mm. Forty-seven women underwent intrauterine infusion of autologous PRP gel on three occasions during endometrial preparation and the remaining women served as controls. The final EMT was measured by ultrasound before the start of the luteal phase, and FET-related outcome parameters were monitored.

Results

Mean EMT was greater in women who received PRP gel than in those who did not (6.7 mm vs. 6.3 mm, respectively, p < 0.05). FET was attempted in all women. The 47 women who underwent infusion of PRP had a significantly higher pregnancy rate (18 pregnancies (38.3%), with 17 (36.2%) ongoing) compared with 64 control women (ten pregnancies (18.5%), nine (16.7%) ongoing). However, there was no significant reduction in the miscarriage rate.

Conclusion

Intrauterine infusion of autologous PRP gel during endometrial preparation for FET cycles can improve the EMT, clinical pregnancy rate, and ongoing pregnancy rate in women with thin endometrium.

Abstract Image

宫腔内注入自体富血小板血浆凝胶对子宫内膜厚度和子宫内膜薄妇女冻融胚胎移植结果的影响
本研究的目的是确定宫腔内输注自体富血小板血浆(PRP)凝胶是否会增加子宫内膜厚度(EMT)并改善子宫内膜薄的女性冷冻-解冻胚胎移植(FET)的结果。所有患者以前至少有一个周期因子宫内膜薄或以前的胚胎移植周期而被取消,EMT < 7 mm。47名妇女在子宫内膜准备期间接受了三次宫腔内注射自体PRP凝胶,其余妇女作为对照组。结果接受PRP凝胶治疗的妇女的平均EMT大于未接受治疗的妇女(分别为6.7 mm vs. 6.3 mm,p <0.05)。所有女性都尝试了 FET。与 64 名对照组女性(10 人怀孕(18.5%),9 人正在怀孕(16.7%))相比,47 名输注了 PRP 的女性怀孕率明显更高(18 人怀孕(38.3%),17 人(36.2%)正在怀孕)。结论在为 FET 周期进行子宫内膜准备期间,宫腔注射自体 PRP 凝胶可改善薄子宫内膜妇女的 EMT、临床妊娠率和持续妊娠率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.20
自引率
4.30%
发文量
567
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