The role of RNA modifications in disease-associated macrophages

IF 6.5 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Molecular Therapy. Nucleic Acids Pub Date : 2024-08-26 DOI:10.1016/j.omtn.2024.102315

Camille Huart, Mayuk Saibal Gupta, Jo A. Van Ginderachter

引用次数: 0

Abstract

In recent years, the field of epitranscriptomics has witnessed significant breakthroughs with the identification of more than 150 different chemical modifications in different RNA species. It has become increasingly clear that these chemical modifications play an important role in the regulation of fundamental processes linked to cell fate and development. Further interest was sparked by the ability of the epitranscriptome to regulate pathogenesis. However, despite the involvement of macrophages in a multitude of diseases, a clear knowledge gap exists in the understanding of how RNA modifications regulate the phenotype of these cells. Here, we provide a comprehensive overview of the known roles of macrophage RNA modifications in the context of different diseases.

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RNA 修饰在疾病相关巨噬细胞中的作用

近年来，表转录组学领域取得了重大突破，在不同种类的 RNA 中鉴定出 150 多种不同的化学修饰。人们越来越清楚地认识到，这些化学修饰在调控与细胞命运和发育相关的基本过程中发挥着重要作用。表观转录组调控致病机理的能力进一步激发了人们的兴趣。然而，尽管巨噬细胞参与了多种疾病，但在了解 RNA 修饰如何调控这些细胞的表型方面仍存在明显的知识空白。在此，我们将全面概述巨噬细胞 RNA 修饰在不同疾病中的已知作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Therapy. Nucleic Acids MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

15.40

自引率

1.10%

发文量

336

审稿时长

20 weeks

期刊介绍： Molecular Therapy Nucleic Acids is an international, open-access journal that publishes high-quality research in nucleic-acid-based therapeutics to treat and correct genetic and acquired diseases. It is the official journal of the American Society of Gene & Cell Therapy and is built upon the success of Molecular Therapy. The journal focuses on gene- and oligonucleotide-based therapies and publishes peer-reviewed research, reviews, and commentaries. Its impact factor for 2022 is 8.8. The subject areas covered include the development of therapeutics based on nucleic acids and their derivatives, vector development for RNA-based therapeutics delivery, utilization of gene-modifying agents like Zn finger nucleases and triplex-forming oligonucleotides, pre-clinical target validation, safety and efficacy studies, and clinical trials.