The known and unknown of post-pump chorea: a case report on robust steroid responsiveness implicating occult neuroinflammation

IF 5.7 2区医学 Q1 IMMUNOLOGY

Frontiers in Immunology Pub Date : 2024-09-10 DOI:10.3389/fimmu.2024.1458022

Muhammad Iqbal, Muizz Zaman, Niranjan Ojha, Yung-Tian A. Gau, Eufrosina I. Young

引用次数: 0

Abstract

Post-pump chorea (PPC) is characterized by the development of choreiform movements following cardiopulmonary bypass (CPB) surgery. PPC occurs almost exclusively in children, and its pathophysiology remains unclear. Here we present an adult case of PPC after bovine aortic valve replacement (AVR) which exhibited dramatic and reproducible response to steroid, suggesting the presence of occult neuroinflammation. This observation suggests a novel underlying mechanism in certain subgroups of PPC, which is likely a heterogeneous condition to start with. Further research into the pathomechanisms of PPC could offer insights into managing this otherwise symptomatic control-only condition.

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泵后胆囊炎的已知与未知：关于类固醇反应性强的病例报告，暗示隐性神经炎症

泵后舞蹈症（PPC）的特点是在心肺旁路（CPB）手术后出现舞蹈状运动。PPC 几乎只发生在儿童身上，其病理生理学仍不清楚。在此，我们介绍了一例牛主动脉瓣置换术（AVR）后出现的主动脉瓣关闭不全的成人病例，该病例对类固醇的反应剧烈且具有可重复性，表明存在隐匿性神经炎症。这一观察结果表明，在某些亚组的多发性冠状动脉硬化症中存在一种新的潜在机制，而多发性冠状动脉硬化症很可能是一种异质性疾病。对多发性硬化症病理机制的进一步研究可为治疗这种无症状、仅受控制的病症提供启示。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Immunology IMMUNOLOGY-

CiteScore

9.80

自引率

11.00%

发文量

7153

审稿时长

14 weeks

期刊介绍： Frontiers in Immunology is a leading journal in its field, publishing rigorously peer-reviewed research across basic, translational and clinical immunology. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Immunology is the official Journal of the International Union of Immunological Societies (IUIS). Encompassing the entire field of Immunology, this journal welcomes papers that investigate basic mechanisms of immune system development and function, with a particular emphasis given to the description of the clinical and immunological phenotype of human immune disorders, and on the definition of their molecular basis.