Sex and Age Influence the Relationship Between Serum Creatinine/Cystatin C and Carotid Plaque in Patients With Type 2 Diabetes Mellitus.

IF 2.6 3区医学 Q2 PERIPHERAL VASCULAR DISEASE

Angiology Pub Date : 2024-09-11 DOI:10.1177/00033197241280527

Dan Yang,Kexin Li,Qiujuan Zhang,Tian Yu,Ling Liu,You Wang,Shuyuan Kang,Shumiao Song,Baofeng Xu,Rui Liu

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Abstract

We investigated the effect of sex and age on the association between serum creatinine/cystatin C (CCR) ratio and carotid plaque in patients with type 2 diabetes mellitus (T2DM). The carotid plaque group and the non-plaque group were divided according to cervical vascular ultrasound; the general and biochemical data of the two groups were compared according to CCR, gender, and age. Binary logistic regression was used to analyze the factors influencing carotid plaque. A total of 1429 patients with T2DM were included in this study. On multivariate analysis, CCR was an independent predictor of carotid plaque with an adjusted odds ratio (OR) of 1.681 [1.250-2.260]. The risk of carotid plaque in men with T2DM increased significantly (P < .05) with decreasing levels of CCR. In addition, an association between CCR and carotid plaque was found in individuals with T2DM <65 years of age (P < .05). CCR is strongly associated with the risk of carotid plaques in persons with T2DM and are an independent risk factor for carotid plaques in men and people aged <65 years with T2DM.

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性别和年龄影响 2 型糖尿病患者血清肌酸酐/胱抑素 C 与颈动脉斑块之间的关系

我们研究了性别和年龄对 2 型糖尿病（T2DM）患者血清肌酐/胱抑素 C（CCR）比值与颈动脉斑块之间关系的影响。根据颈部血管超声分为颈动脉斑块组和非斑块组，并根据 CCR、性别和年龄比较两组的一般和生化数据。采用二元逻辑回归分析颈动脉斑块的影响因素。本研究共纳入了 1429 名 T2DM 患者。经多变量分析，CCR是颈动脉斑块的独立预测因素，调整后的比值比（OR）为1.681 [1.250-2.260]。患有 T2DM 的男性患颈动脉斑块的风险随着 CCR 水平的降低而显著增加（P < .05）。此外，在年龄小于 65 岁的 T2DM 患者中也发现了 CCR 与颈动脉斑块之间的关联（P < .05）。CCR与T2DM患者颈动脉斑块的风险密切相关，是男性和年龄小于65岁的T2DM患者颈动脉斑块的独立风险因素。

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来源期刊

Angiology 医学-外周血管病

CiteScore

5.50

自引率

14.30%

发文量

180

审稿时长

6-12 weeks

期刊介绍： A presentation of original, peer-reviewed original articles, review and case reports relative to all phases of all vascular diseases, Angiology (ANG) offers more than a typical cardiology journal. With approximately 1000 pages per year covering diagnostic methods, therapeutic approaches, and clinical and laboratory research, ANG is among the most informative publications in the field of peripheral vascular and cardiovascular diseases. This journal is a member of the Committee on Publication Ethics (COPE). Average time from submission to first decision: 13 days