Jiayu Zhang, Jie Xiong, Min Wang, Bin Wu, Chunyin Zhang
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引用次数: 0
Abstract
Objective
Although 18F-FDG PET/CT is helpful in detecting primary breast cancer and its distant metastases, 68Ga-FAPI PET/CT may perform better in detecting primary breast cancers at an earlier stage and metastatic lesions (lymph node, etc.). This study aimed to systematically review the diagnostic value of 68Ga-FAPI PET/CT versus 18F-FDG PET/CT in terms of diagnostic accuracy parameters (sensitivity, specificity) and quantitative parameters (SUVmax, TBR, etc.) for the diagnosis of primary and metastatic lesions of breast cancer.
Methods
This study followed the PRISMA guidelines for systematic reviews. A comprehensive search of the PubMed, EMBASE and Web of Science databases was performed to identify studies that met the eligibility criteria from 2000–01 to 2023–07. The quality of the relevant studies with the QUADAS-2 method was assessed via ReviewManager v.5 software. The literature included female breast cancer patients with the pathologic type of invasive carcinoma who had received both 18F-FDG and 68Ga-FAPI PET/CT.
Results
A total of 238 documents were retrieved, and 6 were ultimately included. The results revealed that 68Ga-FAPI PET/CT had a greater SUVmax, TBR, and sensitivity than FDG did.
Conclusion
In this study, we compared the value of 68Ga-FAPI PET/CT and 18F-FDG PET/CT in breast cancer patients. For both primary and metastatic foci of breast cancer, 68Ga-FAPI PET/CT resulted in a higher lesion detection rate and tracer uptake. Second, 68Ga-FAPI PET/CT can improve patient staging and provide some prognostic information, including the pathological response. In addition, 68Ga-FAPI PET/CT imaging can detect additional lesions as a complementary tool.
期刊介绍：
Clinical and Translational Imaging is an international journal that publishes timely, up-to-date summaries on clinical practice and translational research and clinical applications of approved and experimental radiopharmaceuticals for diagnostic and therapeutic purposes. Coverage includes such topics as advanced preclinical evidence in the fields of physics, dosimetry, radiation biology and radiopharmacy with relevance to applications in human subjects. The journal benefits a readership of nuclear medicine practitioners and allied professionals involved in molecular imaging and therapy.
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