Assessment of chromatography separation parameters in the quality control of copper-64-labeled neurotensin-like peptides

IF 1.5 3区化学 Q3 CHEMISTRY, ANALYTICAL

Journal of Radioanalytical and Nuclear Chemistry Pub Date : 2024-09-13 DOI:10.1007/s10967-024-09694-1

Maria-Roxana Tudoroiu-Cornoiu, Elena Livia Chilug, Diana Cocioabă, Simona Băruţă, Radu Şerban, Alina Catrinel Ion, Dana Niculae

引用次数: 0

Abstract

In recent years, research on the Cu-64 effects on malignant tumours has increased, leading to the development of radiopharmaceuticals with higher selectivity, aiming to target tumour cells while preserving healthy body cells. This work aims to assess the quality of two DOTA-derivatized neuropeptides, NMN and NT (8-13) radiolabelled with Cu-64. An improved analytical radio-HPLC method was developed to evaluate the radiochemical purity and stability. The radiochemical purity is > 99.95% for both ⁶⁴Cu-DOTA-NMN and ⁶⁴Cu-DOTA-NT (8-13), the radiolabelled molecules being stable for 72 h after synthesis.

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铜-64标记神经肽质量控制中的色谱分离参数评估

近年来，有关 Cu-64 对恶性肿瘤影响的研究日益增多，促使人们开发出具有更高选择性的放射性药物，旨在靶向肿瘤细胞的同时保留健康的体细胞。这项研究旨在评估两种用 Cu-64 放射性标记的 DOTA 衍生化神经肽 NMN 和 NT (8-13) 的质量。研究人员开发了一种改进的放射-高效液相色谱分析方法，用于评估放射化学纯度和稳定性。64Cu-DOTA-NMN 和 64Cu-DOTA-NT (8-13) 的放射化学纯度均为 99.95%，放射性标记的分子在合成后 72 小时内保持稳定。

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来源期刊

Journal of Radioanalytical and Nuclear Chemistry 化学-分析化学

CiteScore

2.80

自引率

18.80%

发文量

504

审稿时长

2.2 months

期刊介绍： An international periodical publishing original papers, letters, review papers and short communications on nuclear chemistry. The subjects covered include: Nuclear chemistry, Radiochemistry, Radiation chemistry, Radiobiological chemistry, Environmental radiochemistry, Production and control of radioisotopes and labelled compounds, Nuclear power plant chemistry, Nuclear fuel chemistry, Radioanalytical chemistry, Radiation detection and measurement, Nuclear instrumentation and automation, etc.