Brain abscesses: the first report of disseminated Nocardia beijingensis infection in an immunocompetent individual in China

IF 2.2 3区医学 Q3 CLINICAL NEUROLOGY

BMC Neurology Pub Date : 2024-09-13 DOI:10.1186/s12883-024-03826-6

Lihong Jin, Weiqun Zhang, Fang Su, Youqi Ji, Yumei Ge

{"title":"Brain abscesses: the first report of disseminated Nocardia beijingensis infection in an immunocompetent individual in China","authors":"Lihong Jin, Weiqun Zhang, Fang Su, Youqi Ji, Yumei Ge","doi":"10.1186/s12883-024-03826-6","DOIUrl":null,"url":null,"abstract":"Nocardia is widely distributed in the natural environment and typically cause opportunistic infections. However, it is important to note that the pathogenicity of different Nocardia species may vary significantly. Here we reported the first case of brain abscess caused by Nocardia beijingensis (N. beijingensis) infection in China. A 70-year-old male immunocompetent individual came to our hospital for treatment due to headache. After examination, it was found that he had a brain abscess caused by N. beijingensis. By utilizing a combination of surgical intervention and antibiotic therapy, the patient ultimately achieved full recovery. In addition, we isolated this strain and displayed its ultrastructure through scanning electron microscopy. The phylogenetic tree was analyzed by 16 S rRNA sequence. A literature review of N. beijingensis infections in all immunocompetent and immunocompromised patients was presented. It highlighted that abscess formation appears to be a common manifestation of N. beijingensis infection, and N. beijingensis has become an emerging pathogen in immunocompetent individuals.","PeriodicalId":9170,"journal":{"name":"BMC Neurology","volume":null,"pages":null},"PeriodicalIF":2.2000,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Neurology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12883-024-03826-6","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Nocardia is widely distributed in the natural environment and typically cause opportunistic infections. However, it is important to note that the pathogenicity of different Nocardia species may vary significantly. Here we reported the first case of brain abscess caused by Nocardia beijingensis (N. beijingensis) infection in China. A 70-year-old male immunocompetent individual came to our hospital for treatment due to headache. After examination, it was found that he had a brain abscess caused by N. beijingensis. By utilizing a combination of surgical intervention and antibiotic therapy, the patient ultimately achieved full recovery. In addition, we isolated this strain and displayed its ultrastructure through scanning electron microscopy. The phylogenetic tree was analyzed by 16 S rRNA sequence. A literature review of N. beijingensis infections in all immunocompetent and immunocompromised patients was presented. It highlighted that abscess formation appears to be a common manifestation of N. beijingensis infection, and N. beijingensis has become an emerging pathogen in immunocompetent individuals.

查看原文本刊更多论文

脑脓肿：中国首次报告免疫功能正常者感染播散性北京诺卡氏菌

诺卡氏菌广泛分布于自然环境中，通常会引起机会性感染。然而，值得注意的是，不同种类的诺卡氏菌的致病性可能存在很大差异。在此，我们报告了中国首例由北京诺卡菌（N. beijingensis）感染引起的脑脓肿病例。一名 70 岁的男性免疫功能正常者因头痛来我院就诊。经检查发现，他患有由北京诺卡菌引起的脑脓肿。通过外科手术和抗生素综合治疗，患者最终完全康复。此外，我们还分离出了这一菌株，并通过扫描电子显微镜展示了其超微结构。通过 16 S rRNA 序列分析了该菌株的系统发生树。文献综述了所有免疫功能健全和免疫功能低下患者感染北京痢疾杆菌的情况。它强调了脓肿形成似乎是北京痢疾杆菌感染的常见表现，北京痢疾杆菌已成为免疫功能健全者的一种新病原体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

BMC Neurology 医学-临床神经学

CiteScore

4.20

自引率

0.00%

发文量

428

审稿时长

3-8 weeks

期刊介绍： BMC Neurology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of neurological disorders, as well as related molecular genetics, pathophysiology, and epidemiology.