Synergistic effect of chromium–nickel based organic frameworks toward an effective electrochemical determination of flutamide in environmental samples

IF 2.7 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Journal of Materials Research Pub Date : 2024-09-06 DOI:10.1557/s43578-024-01421-6

Navaneeth Kumar Ravikumar, Panneerselvam Perumal

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Abstract

An innovative electrochemical sensor has been developed using Cr–Ni bimetal-organic frameworks (MOFs) for detecting the anti-prostate cancer medication, flutamide, in environmental samples. The sensor utilizes a modified glassy carbon electrode (GCE). The Cr–Ni MOF-modified electrode demonstrated significantly higher peak currents compared to the bare GCE or electrodes modified with either Cr-MOF or Ni-MOF alone. This enhanced performance is attributed to superior conductivity, robust catalytic capabilities, and the synergistic interactions of bimetals within the organic framework assembly. The sensor was optimized for flutamide detection using differential pulse voltammetry in a phosphate buffer solution at pH 9. It achieved a linear detection range of 10 to 100 μM, a low detection limit (LOD) of 0.09 μM, and a limit of quantification (LOQ) of 0.30 μM. The sensor also demonstrated high stability, specificity, and reproducibility.

Graphical Abstract

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铬镍基有机框架对有效电化学测定环境样品中氟胺的协同效应

利用铬镍双金属有机框架（MOFs）开发了一种创新型电化学传感器，用于检测环境样品中的抗前列腺癌药物氟他胺。该传感器采用改性玻璃碳电极（GCE）。与裸 GCE 或单独使用 Cr-MOF 或 Ni-MOF 修饰的电极相比，Cr-Ni MOF 修饰的电极显示出更高的峰值电流。性能的提高归功于卓越的导电性、强大的催化能力以及有机框架组件中双金属的协同作用。在 pH 值为 9 的磷酸盐缓冲溶液中使用差分脉冲伏安法对该传感器进行了优化，其线性检测范围为 10 至 100 μM，低检测限 (LOD) 为 0.09 μM，定量限 (LOQ) 为 0.30 μM。该传感器还具有高稳定性、特异性和可重复性。

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来源期刊

Journal of Materials Research 工程技术-材料科学：综合

CiteScore

4.50

自引率

3.70%

发文量

362

审稿时长

2.8 months

期刊介绍： Journal of Materials Research (JMR) publishes the latest advances about the creation of new materials and materials with novel functionalities, fundamental understanding of processes that control the response of materials, and development of materials with significant performance improvements relative to state of the art materials. JMR welcomes papers that highlight novel processing techniques, the application and development of new analytical tools, and interpretation of fundamental materials science to achieve enhanced materials properties and uses. Materials research papers in the following topical areas are welcome. • Novel materials discovery • Electronic, photonic and magnetic materials • Energy Conversion and storage materials • New thermal and structural materials • Soft materials • Biomaterials and related topics • Nanoscale science and technology • Advances in materials characterization methods and techniques • Computational materials science, modeling and theory