Cassandra M. Joynes, Murat Bilgel, Yang An, Abhay R. Moghekar, Nicholas J. Ashton, Przemysław R. Kac, Thomas K. Karikari, Kaj Blennow, Henrik Zetterberg, Madhav Thambisetty, Luigi Ferrucci, Susan M. Resnick, Keenan A. Walker
{"title":"Sex differences in the trajectories of plasma biomarkers, brain atrophy, and cognitive decline relative to amyloid onset","authors":"Cassandra M. Joynes, Murat Bilgel, Yang An, Abhay R. Moghekar, Nicholas J. Ashton, Przemysław R. Kac, Thomas K. Karikari, Kaj Blennow, Henrik Zetterberg, Madhav Thambisetty, Luigi Ferrucci, Susan M. Resnick, Keenan A. Walker","doi":"10.1101/2024.09.03.24312664","DOIUrl":null,"url":null,"abstract":"<strong>INTRODUCTION</strong> The factors that influence the progression of Alzheimer’s disease (AD) after individuals become amyloid-positive are poorly understood. This study examines how sex influences the longitudinal trajectories of plasma AD and neurodegenerative biomarkers in the years following a person’s estimated onset of amyloid-β.","PeriodicalId":501071,"journal":{"name":"medRxiv - Epidemiology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv - Epidemiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.09.03.24312664","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
INTRODUCTION The factors that influence the progression of Alzheimer’s disease (AD) after individuals become amyloid-positive are poorly understood. This study examines how sex influences the longitudinal trajectories of plasma AD and neurodegenerative biomarkers in the years following a person’s estimated onset of amyloid-β.