New Bioactive Polyketides from the Mangrove-Derived Fungus Penicillium sp. SCSIO 41411

IF 4.9 2区医学 Q1 CHEMISTRY, MEDICINAL

Marine Drugs Pub Date : 2024-08-26 DOI:10.3390/md22090384

Yi Chen, Jian Cai, Ziwei Xia, Chunmei Chen, Yonghong Liu, Lalith Jayasinghe, Xueni Wang, Xuefeng Zhou

引用次数: 0

Abstract

Three new polyketides, including three ester derivatives (1, 3, and 5) and a new natural product, which was a benzoquinone derivative, embelin A (4), together with nine known ones (2 and 6–13), were isolated from the mangrove-derived fungus Penicillium sp. SCSIO 41411. Their structures were determined by detailed NMR and MS spectroscopic analyses. The X-ray single-crystal diffraction analysis of 4 was described for the first time. Compound 9 displayed obvious inhibition against PDE4 with an inhibitory ratio of 40.78% at 10 μM. Compound 12 showed DPPH radical scavenging activity, with an EC50 of 16.21 µg/mL, compared to the positive control (ascorbic acid, EC50, 11.22 µg/mL). Furthermore, compound 4 exhibited cytotoxicity against PC-3 and LNCaP with IC50 values of 18.69 and 31.62 µM, respectively.

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源自红树林的真菌青霉 SCSIO 41411 的新型生物活性多酮化合物

从源自红树林的真菌青霉菌（Penicillium sp. SCSIO 41411）中分离出了三种新的多酮类化合物，包括三种酯类衍生物（1、3 和 5）和一种新的天然产物，即苯醌衍生物 embelin A（4），以及九种已知的多酮类化合物（2 和 6-13）。通过详细的核磁共振和质谱分析确定了它们的结构。首次描述了 4 的 X 射线单晶衍射分析。化合物 9 对 PDE4 有明显的抑制作用，在 10 μM 时抑制率为 40.78%。化合物 12 具有 DPPH 自由基清除活性，与阳性对照（抗坏血酸，EC50 为 11.22 µg/mL）相比，EC50 为 16.21 µg/mL。此外，化合物 4 对 PC-3 和 LNCaP 具有细胞毒性，IC50 值分别为 18.69 和 31.62 µM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Marine Drugs 医学-医药化学

CiteScore

9.60

自引率

14.80%

发文量

671

审稿时长

1 months

期刊介绍： Marine Drugs (ISSN 1660-3397) publishes reviews, regular research papers and short notes on the research, development and production of drugs from the sea. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible, particularly synthetic procedures and characterization information for bioactive compounds. There is no restriction on the length of the experimental section.