Good response to cadonilimab as first-line treatment in superaged patient with advanced gastric cancer: a case report.

IF 2.7 4区医学 Q3 IMMUNOLOGY

Immunotherapy Pub Date : 2024-09-11 DOI:10.1080/1750743x.2024.2394405

Jia Lun,Guikai Ma,Xuan Wang,Qian Wang

引用次数: 0

Abstract

Gastric cancer remains a considerable global health burden, with limited treatment options available for advanced cases, especially for superaged patients. Cadonilimab, a first-in-class bi-specific antibody (BsAb), offer a promising immunotherapy approach by targeting PD-1/CTLA-4 simultaneously. Herein, we present a case report of an 85-year-old patient with HER2-negative advanced gastric cancer who received first-line treatment with cadonilimab combined with chemotherapy, but cadonilimab was discontinued due to the observation of immune-related pneumonitis during treatment. Despite these changes, the patient still exhibited a stable disease condition for a year until now. This case report highlights the potential of cadonilimab in the treatment of superaged patients with advanced gastric cancer, while the efficacy and safety of it need to be further evaluated.

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晚期胃癌超高龄患者对卡多尼单抗一线治疗的良好反应：病例报告。

胃癌仍然是一个相当大的全球健康负担，晚期病例，尤其是高龄患者的治疗方案有限。卡多尼单抗（Cadonilimab）是一种首创的双特异性抗体（BsAb），可同时靶向PD-1/CTLA-4，是一种前景广阔的免疫疗法。在此，我们报告了一例 85 岁 HER2 阴性晚期胃癌患者的病例，该患者接受了卡多尼单抗联合化疗的一线治疗，但由于在治疗期间观察到免疫相关性肺炎，卡多尼单抗被停用。尽管出现了这些变化，该患者一年来病情仍然稳定，直到现在。本病例报告凸显了卡多尼单抗治疗超高龄晚期胃癌患者的潜力，但其疗效和安全性仍有待进一步评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunotherapy 医学-免疫学

CiteScore

5.00

自引率

3.60%

发文量

113

审稿时长

6-12 weeks

期刊介绍： Many aspects of the immune system and mechanisms of immunomodulatory therapies remain to be elucidated in order to exploit fully the emerging opportunities. Those involved in the research and clinical applications of immunotherapy are challenged by the huge and intricate volumes of knowledge arising from this fast-evolving field. The journal Immunotherapy offers the scientific community an interdisciplinary forum, providing them with information on the most recent advances of various aspects of immunotherapies, in a concise format to aid navigation of this complex field. Immunotherapy delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this vitally important area of research. Unsolicited article proposals are welcomed and authors are required to comply fully with the journal''s Disclosure & Conflict of Interest Policy as well as major publishing guidelines, including ICMJE and GPP3.