Tissue-resident memory T cells: Harnessing their properties against infection for cancer treatment

IF 3.2 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

BioEssays Pub Date : 2024-09-11 DOI:10.1002/bies.202400119

João Fernandes, Marc Veldhoen, Cristina Ferreira

引用次数: 0

Abstract

We have rapidly gained insights into the presence and function of T lymphocytes in non-lymphoid tissues, the tissue-resident memory T (T_RM) cells. The central pillar of adaptive immunity has been expanded from classic central memory T cells giving rise to progeny upon reinfection and effector memory cells circulating through the blood and patrolling the tissues to include T_RM cells that reside and migrate inside solid organs and tissues. Their development and maintenance have been studied in detail, providing exciting clues on how their unique properties used to fight infections may benefit therapies against solid tumors. We provide an overview of CD8 T_RM cells and the properties that make them of interest for vaccination and cancer therapies.

Abstract Image

查看原文本刊更多论文

组织驻留记忆 T 细胞：利用其抗感染特性治疗癌症

我们对非淋巴组织中T淋巴细胞（组织驻留记忆T细胞（TRM））的存在和功能有了迅速深入的了解。适应性免疫的核心支柱已经从传统的再感染时产生后代的中心记忆 T 细胞和在血液中循环并在组织中巡逻的效应记忆细胞，扩展到包括在实体器官和组织中驻留和迁移的 TRM 细胞。我们对这些细胞的发育和维持进行了详细研究，并提供了令人兴奋的线索，说明这些细胞用于抗感染的独特特性如何有益于实体瘤疗法。我们将概述 CD8 TRM 细胞以及它们在疫苗接种和癌症疗法中的特性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

BioEssays 生物-生化与分子生物学

CiteScore

7.30

自引率

2.50%

发文量

167

审稿时长

4-8 weeks

期刊介绍： molecular – cellular – biomedical – physiology – translational research – systems - hypotheses encouraged BioEssays is a peer-reviewed, review-and-discussion journal. Our aims are to publish novel insights, forward-looking reviews and commentaries in contemporary biology with a molecular, genetic, cellular, or physiological dimension, and serve as a discussion forum for new ideas in these areas. An additional goal is to encourage transdisciplinarity and integrative biology in the context of organismal studies, systems approaches, through to ecosystems, where appropriate.