A Single Center Observational Study on 25-hydroxyvitamin D levels in Meniscus Injury Patients

shuaishuai hu, Duzheng Zhang, Ruijun Cong
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Abstract

There is limited research on the association between 25-hydroxyvitamin D levels and meniscus injury. This study investigated serum 25-hydroxyvitamin D (25-OHD) in meniscus injury patients and its association with other bioinorganic chemistry of micronutrients, and immune cells numbers from January 2023 to December 2023. A total of 198 participants were recruited between the age of 18 and 89 years. Participants with renal or liver failure, or any other chronic conditions, who were taking medications that might affect the metabolism of vitamin D, were not included in the study. In this study, we categorized serum 25(OH)D concentrations as follows: ≤30ngm/dl was categorized as insufficient, and >30ngm/dl was deemed sufficient. Among the 198 participants, 82% (n=162) were serum 25(OH)D deficient, while only 18% (n=36) participants were serum 25(OH)D sufficient. No significant difference observed in vitamin D deficiency among difference age, BMI, sex, blood pressure, inflammatory cell numbers, and other vitamins compared to the vitamin D sufficient group. Moreover, the serum 25(OH)D concentrations were negatively related to the severity of meniscus injury based on MRI examination. In conclusion, severe vitamin D deficiency is more common in patients with meniscus injury and may play a significant role in their prognosis.
关于半月板损伤患者体内 25- 羟维生素 D 水平的单中心观察研究
关于 25- 羟基维生素 D 水平与半月板损伤之间关系的研究十分有限。本研究调查了 2023 年 1 月至 2023 年 12 月期间半月板损伤患者的血清 25- 羟维生素 D(25-OHD)及其与其他生物无机化学微量元素和免疫细胞数量的关系。共招募了 198 名年龄在 18 至 89 岁之间的参与者。患有肾功能衰竭、肝功能衰竭或任何其他慢性疾病的参与者,以及正在服用可能影响维生素 D 代谢的药物的参与者未被纳入研究。在这项研究中,我们将血清 25(OH)D 浓度分为以下几类:≤30ngm/dl为不足,>30ngm/dl为充足。在 198 名参与者中,82%(n=162)的人血清中 25(OH)D 不足,而只有 18%(n=36)的人血清中 25(OH)D 充足。与维生素 D 充足组相比,年龄、体重指数、性别、血压、炎症细胞数量和其他维生素的缺乏情况没有明显差异。此外,根据核磁共振成像检查,血清 25(OH)D 浓度与半月板损伤的严重程度呈负相关。总之,维生素 D 严重缺乏在半月板损伤患者中更为常见,并可能对其预后产生重要影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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