27-Hydroxycholesterol contributes to hypercholesterolemia-associated aggravation of apical periodontitis in ovariectomized rats and raloxifene counteracts its action

IF 5.4 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

International endodontic journal Pub Date : 2024-09-10 DOI:10.1111/iej.14143

H.-W. Wang, C.-N. Yang, S.-H. Kok, C.-Y. Hong, C.-T. Shun, E. H.-H. Lai, S.-J. Cheng, H.-Y. Lin, F.-Y. Wu, S.-K. Lin

引用次数: 0

Abstract

The influence of hypercholesterolemia on the development of apical periodontitis (AP) is inconclusive. Recent studies revealed that cholesterol metabolite 27-hydoxycholesterol (27HC) can affect cellular responses to bacterial infections and oestrogen status and raloxifene may influence its action. Herein, we aimed to examine the impact of 27HC on production of inflammatory mediators by macrophages and the regulatory function of raloxifene. The contribution of 27HC to AP development and the therapeutic effect of raloxifene were evaluated in a rat model.

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27-羟基胆固醇导致卵巢切除大鼠与高胆固醇血症相关的根尖牙周炎恶化，而雷洛昔芬可抵消其作用

高胆固醇血症对根尖牙周炎（AP）发病的影响尚无定论。最近的研究发现，胆固醇代谢产物 27-羟基胆固醇（27HC）可影响细胞对细菌感染的反应，而雌激素状态和雷洛昔芬可能会影响其作用。在此，我们旨在研究 27HC 对巨噬细胞产生炎症介质的影响以及雷洛昔芬的调节功能。我们在大鼠模型中评估了 27HC 对 AP 发展的贡献以及雷洛昔芬的治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International endodontic journal 医学-牙科与口腔外科

CiteScore

10.20

自引率

28.00%

发文量

195

审稿时长

4-8 weeks

期刊介绍： The International Endodontic Journal is published monthly and strives to publish original articles of the highest quality to disseminate scientific and clinical knowledge; all manuscripts are subjected to peer review. Original scientific articles are published in the areas of biomedical science, applied materials science, bioengineering, epidemiology and social science relevant to endodontic disease and its management, and to the restoration of root-treated teeth. In addition, review articles, reports of clinical cases, book reviews, summaries and abstracts of scientific meetings and news items are accepted. The International Endodontic Journal is essential reading for general dental practitioners, specialist endodontists, research, scientists and dental teachers.