794. RETROSPECTIVE ANALYSIS OF CLINICAL CHARACTERISTICS AND PROGNOSIS OF SYNCHRONOUS MULTIPLE PRIMARY ESOPHAGEAL SQUAMOUS CELL CARCINOMA

IF 2.3 3区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY
Liu Wenyi, Zhentao Yu
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Abstract

Background Multiple primary esophageal squamous cell carcinoma (MPESCC) is a rare and complex type of esophageal cancer, categorized into synchronous multiple primary esophageal squamous cell carcinoma (S-MPESCC) and metachronous multiple primary esophageal squamous cell carcinoma (M-MPESCC). Compared to solitary esophageal squamous cell carcinoma (SESCC), multiple primary esophageal squamous cell carcinoma (MPESCC) generally has a poorer prognosis, with significant differences in treatment strategies and survival outcomes. This study aims to explore the clinical characteristics and prognosis of S-MPESCC through a retrospective analysis of a large patient cohort. Methods This study retrospectively analyzed clinical data from 758 patients with esophageal squamous cell carcinoma (ESCC) who underwent surgical resection at two medical centers in China from January 2012 to December 2021. The S-MPESCC group included 68 patients, and the SESCC group included 690 patients. All patients underwent radical esophagectomy with systematic lymph node dissection. Preoperative and postoperative data were collected, including gender, age, family history, tumor staging, and lymph node metastasis. Results There were no significant differences in baseline characteristics, such as gender, age, and family history, between the S-MPESCC and SESCC groups. The lymph node metastasis rate was significantly higher in the S-MPESCC group compared to the SESCC group, especially in the upper mediastinal and abdominal regions (P<0.05). Survival status was monitored through outpatient visits and telephone calls until December 2022. The results showed that the 3-year and 5-year survival rates of the S-MPESCC group were significantly lower than those of the SESCC group (P< 0.05). Patients with a greater depth of primary tumor infiltration had poorer survival outcomes in the S-MPESCC group. Conclusion This study clarified the clinical characteristics and prognosis of S-MPESCC through a retrospective analysis of 758 ESCC patients. S-MPESCC patients had a significantly higher rate of lymph node metastasis and a poorer prognosis compared to SESCC patients. Future efforts should focus on optimizing treatment strategies to improve the prognosis and survival rates of patients with S-MPESCC.
794.同步多发性原发性食管鳞状细胞癌临床特征和预后的回顾性分析
背景 多发性原发性食管鳞状细胞癌(MPESCC)是一种罕见而复杂的食管癌,分为同步多发性原发性食管鳞状细胞癌(S-MPESCC)和间变性多发性原发性食管鳞状细胞癌(M-MPESCC)。与单发食管鳞状细胞癌(SESCC)相比,多发性原发性食管鳞状细胞癌(MPESCC)的预后一般较差,治疗策略和生存结果也有显著差异。本研究旨在通过对大型患者队列的回顾性分析,探讨 S-MPESCC 的临床特征和预后。方法 本研究回顾性分析了2012年1月至2021年12月期间在中国两家医疗中心接受手术切除的758例食管鳞状细胞癌(ESCC)患者的临床数据。S-MPESCC组包括68名患者,SESCC组包括690名患者。所有患者均接受了根治性食管切除术和系统性淋巴结清扫术。收集的术前和术后数据包括性别、年龄、家族史、肿瘤分期和淋巴结转移情况。结果 S-MPESCC组和SESCC组在性别、年龄和家族史等基线特征方面无明显差异。S-MPESCC组的淋巴结转移率明显高于SESCC组,尤其是上纵隔和腹腔区域(P<0.05)。在2022年12月之前,通过门诊就诊和电话咨询对患者的生存状况进行监测。结果显示,S-MPESCC 组的 3 年和 5 年生存率明显低于 SESCC 组(P<0.05)。原发肿瘤浸润深度较深的 S-MPESCC 组患者生存率较低。结论 本研究通过对 758 例 ESCC 患者的回顾性分析,阐明了 S-MPESCC 的临床特征和预后。与 SESCC 患者相比,S-MPESCC 患者的淋巴结转移率明显更高,预后更差。今后的工作重点应放在优化治疗策略上,以改善S-MPESCC患者的预后和生存率。
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来源期刊
Diseases of the Esophagus
Diseases of the Esophagus 医学-胃肠肝病学
CiteScore
5.30
自引率
7.70%
发文量
568
审稿时长
6 months
期刊介绍: Diseases of the Esophagus covers all aspects of the esophagus - etiology, investigation and diagnosis, and both medical and surgical treatment.
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