Toxoplasma gondii Seropositivity and Co-Infection with TORCH Complex Pathogens in Pregnant Women from Araçatuba, Brazil

IF 4.1 2区生物学 Q2 MICROBIOLOGY

Microorganisms Pub Date : 2024-09-06 DOI:10.3390/microorganisms12091844

Sabrina Santos Firmino, Thaís Rabelo Santos-Doni, Vitória Maria Farias Silva, Aressa Cassemiro Micheleto, Ma Scalise de Souza, Bruna Lima Hortêncio, Aline do Nascimento Benitez, Yasmin Melim Bento, Gabriele Zaine Teixeira Debortoli, Jancarlo Ferreira Gomes, Italmar Teodorico Navarro, Katia Denise Saraiva Bresciani

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Abstract

This study examined the seropositivity of T. gondii and coinfections with other TORCH pathogens among pregnant women attending 17 Basic Health Units (UBS) in Araçatuba, SP, Brazil. Of the 711 pregnant women seen at these UBS, only 297 were tested for T. gondii. Of the women tested for T. gondii (n = 297), 26.9% had IgG antibodies, 6.7% had IgM, and 32.0% tested positive for either or both. Only 1.4% showed both IgG and IgM antibodies, while 67.7% were non-reactive. The seropositivity was 17.1% for syphilis, 63.2% for rubella, 0.9% for hepatitis C, 0.9% for dengue, 17.9% for COVID-19, and 0.9% for herpes simplex (types 1/2). Coinfections with syphilis, rubella, and herpes simplex were also noted. Higher education levels appeared to protect against T. gondii seropositivity. The findings highlight a significant prevalence of T. gondii among pregnant women, with variation across UBSs, pointing to socioeconomic, behavioral, and environmental factors as influential. We also observed co-occurrence with other infections, such as syphilis, rubella, and herpes simplex. The study underscores the need for targeted public health interventions to reduce the risks of congenital infections.

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巴西阿拉萨图巴孕妇弓形虫血清阳性率和 TORCH 复合病原体合并感染情况

本研究调查了巴西南太平洋州阿拉萨图巴 17 个基本医疗单位（UBS）就诊孕妇的淋病双球菌血清阳性率以及与其他 TORCH 病原体的合并感染情况。在这些 UBS 就诊的 711 名孕妇中，只有 297 人接受了淋病双球菌检测。在接受过淋病双球菌检测的妇女（n = 297）中，26.9% 的人体内有 IgG 抗体，6.7% 的人体内有 IgM 抗体，32.0% 的人体内两种抗体均呈阳性。只有 1.4% 的人同时出现 IgG 和 IgM 抗体，67.7% 的人没有反应。梅毒血清阳性率为 17.1%，风疹为 63.2%，丙型肝炎为 0.9%，登革热为 0.9%，COVID-19 为 17.9%，单纯疱疹（1/2 型）为 0.9%。梅毒、风疹和单纯疱疹的合并感染也有出现。较高的教育水平似乎可以防止淋病双球菌血清阳性。研究结果表明，T. gondii 在孕妇中的流行率很高，不同的 UBS 之间存在差异，表明社会经济、行为和环境因素对其有影响。我们还观察到与梅毒、风疹和单纯疱疹等其他感染并发的情况。这项研究强调，有必要采取有针对性的公共卫生干预措施，以降低先天性感染的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microorganisms Medicine-Microbiology (medical)

CiteScore

7.40

自引率

6.70%

发文量

2168

审稿时长

20.03 days

期刊介绍： Microorganisms (ISSN 2076-2607) is an international, peer-reviewed open access journal which provides an advanced forum for studies related to prokaryotic and eukaryotic microorganisms, viruses and prions. It publishes reviews, research papers and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.

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