The Fracture Phenotypes in Women and Men of 50 Years and Older with a Recent Clinical Fracture

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Current Osteoporosis Reports Pub Date : 2024-09-10 DOI:10.1007/s11914-024-00885-z

P. Geusens, J. van den Bergh, C. Roux, R. Chapurlat, J. Center, D. Bliuc, C. Wyers, M. K. Javaid, N. Li, D. Whittier, W. F. Lems

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Abstract

Purpose of Review

We review the literature about patients 50 years and older with a recent clinical fracture for the presence of skeletal and extra-skeletal risks, their perspectives of imminent subsequent fracture, falls, mortality, and other risks, and on the role of the fracture liaison service (FLS) for timely secondary fracture prevention.

Recent Findings

Patients with a recent clinical fracture present with heterogeneous patterns of bone-, fall-, and comorbidity-related risks. Short-term perspectives include bone loss, increased risk of fractures, falls, and mortality, and a decrease in physical performance and quality of life. Combined evaluation of bone, fall risk, and the presence of associated comorbidities contributes to treatment strategies.

Summary

Since fractures are related to interactions of bone-, fall-, and comorbidity-related risks, there is no one-single-discipline-fits-all approach but a need for a multidisciplinary approach at the FLS to consider all phenotypes for evaluation and treatment in an individual patient.

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近期发生临床骨折的 50 岁及以上女性和男性的骨折表型

综述目的我们综述了有关 50 岁及以上近期临床骨折患者的文献，以了解他们是否存在骨骼和骨骼外风险，他们对即将发生的后续骨折、跌倒、死亡率和其他风险的看法，以及骨折联络服务（FLS）在及时预防二次骨折方面的作用。短期来看，患者会出现骨质流失，骨折、跌倒和死亡风险增加，身体机能和生活质量下降。总结由于骨折与骨骼、跌倒和合并症相关风险的相互作用有关，因此没有一种单一学科适合所有患者的方法，而是需要在 FLS 采用多学科方法，考虑所有表型，对患者进行评估和治疗。

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来源期刊

Current Osteoporosis Reports Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

8.80

自引率

2.30%

发文量

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of osteoporosis. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as current and future therapeutics, epidemiology and pathophysiology, and evaluation and management. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.