Synthesis and photodynamic properties of 5-ALA/g-C3N4@1 supramolecular photosensitizer with potential application in chronic hepatitis B treatment

IF 2.1 4区材料科学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of Nanoparticle Research Pub Date : 2024-09-03 DOI:10.1007/s11051-024-06121-0

Xujin Zhu, Xiaofeng Cheng, Weizhen Zhu

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Abstract

The development of activatable nanoplatforms to enhance diagnostic and therapeutic performance while minimizing side effects is of great significance in treatment of chronic hepatitis B (CHB). Here, we report a novel nanomaterial composed of graphitic carbon nitride (g-C₃N₄) and 5-aminolevulinic acid (5-ALA), onto which our newly synthesized compound 1 is loaded, forming 5-ALA/g-C₃N₄@1. This nanomaterial is highly pH-sensitive and can rapidly degrade in mildly acidic environments, enabling the release of its loaded photosensitizer and compound 1, exhibiting characteristics such as fluorescence recovery and increased singlet oxygen generation. We evaluated the bioactivity of this novel composite material and explored its mechanisms of action. The effect of 5-ALA/g-C₃N₄@1 on the levels of HBV DNA, HBsAg and HBeAg was evaluated by treatment of HepG2.2.15 cells with the system. Our results suggest that the system can effectively inhibit HBV replication for the treatment of CHB. This work presents a novel photosensitive carrier with excellent biocompatibility and therapeutic efficacy, offering new insights into CHB research.

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5-ALA/g-C3N4@1 超分子光敏剂的合成与光动力特性及其在慢性乙型肝炎治疗中的潜在应用

开发可激活的纳米平台以提高诊断和治疗性能，同时最大限度地减少副作用，这对慢性乙型肝炎（CHB）的治疗具有重要意义。在此，我们报告了一种由石墨氮化碳（g-C3N4）和 5-aminolevulinic acid（5-ALA）组成的新型纳米材料，并在其上负载了我们新合成的化合物 1，形成了 5-ALA/g-C3N4@1。这种纳米材料具有高度的 pH 敏感性，可在弱酸性环境中快速降解，使负载的光敏剂和化合物 1 得以释放，并表现出荧光恢复和单线态氧生成增加等特性。我们评估了这种新型复合材料的生物活性，并探索了其作用机制。通过用该系统处理 HepG2.2.15 细胞，评估了 5-ALA/g-C3N4@1 对 HBV DNA、HBsAg 和 HBeAg 水平的影响。结果表明，该系统能有效抑制 HBV 复制，用于治疗慢性阻塞性肺病。这项研究提出了一种具有良好生物相容性和治疗效果的新型光敏载体，为慢性阻塞性肺病的研究提供了新的视角。

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来源期刊

Journal of Nanoparticle Research 工程技术-材料科学：综合

CiteScore

4.40

自引率

4.00%

发文量

198

审稿时长

3.9 months

期刊介绍： The objective of the Journal of Nanoparticle Research is to disseminate knowledge of the physical, chemical and biological phenomena and processes in structures that have at least one lengthscale ranging from molecular to approximately 100 nm (or submicron in some situations), and exhibit improved and novel properties that are a direct result of their small size. Nanoparticle research is a key component of nanoscience, nanoengineering and nanotechnology. The focus of the Journal is on the specific concepts, properties, phenomena, and processes related to particles, tubes, layers, macromolecules, clusters and other finite structures of the nanoscale size range. Synthesis, assembly, transport, reactivity, and stability of such structures are considered. Development of in-situ and ex-situ instrumentation for characterization of nanoparticles and their interfaces should be based on new principles for probing properties and phenomena not well understood at the nanometer scale. Modeling and simulation may include atom-based quantum mechanics; molecular dynamics; single-particle, multi-body and continuum based models; fractals; other methods suitable for modeling particle synthesis, assembling and interaction processes. Realization and application of systems, structures and devices with novel functions obtained via precursor nanoparticles is emphasized. Approaches may include gas-, liquid-, solid-, and vacuum-based processes, size reduction, chemical- and bio-self assembly. Contributions include utilization of nanoparticle systems for enhancing a phenomenon or process and particle assembling into hierarchical structures, as well as formulation and the administration of drugs. Synergistic approaches originating from different disciplines and technologies, and interaction between the research providers and users in this field, are encouraged.