Modular, Scalable Total Synthesis of Neopetromin†

IF 5.5 1区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chinese Journal of Chemistry Pub Date : 2024-08-21 DOI:10.1002/cjoc.202400637

Hiroshige Ogawa, Yuuya Nagata, Hugh Nakamura

引用次数: 0

Abstract

The first total synthesis of neopetromin, featuring the highly strained Tyr C-6-to-Trp N-1’ linkage, is hereby reported. This modular synthetic strategy, employing C—H arylation and Larock macrocyclization, offers a novel approach to the synthesis of various RiPPs natural product families.

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模块化、可扩展的 Neopetromin† 全合成技术

综合摘要本文首次报道了以高度紧张的 Tyr C-6 到 Trp N-1' 连接为特征的 neopetromin 的全合成。这种采用 C-H 芳基化和 Larock 大环化的模块化合成策略为合成各种 RiPPs 天然产物家族提供了一种新方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chinese Journal of Chemistry 化学-化学综合

CiteScore

8.80

自引率

14.80%

发文量

422

审稿时长

1.7 months

期刊介绍： The Chinese Journal of Chemistry is an international forum for peer-reviewed original research results in all fields of chemistry. Founded in 1983 under the name Acta Chimica Sinica English Edition and renamed in 1990 as Chinese Journal of Chemistry, the journal publishes a stimulating mixture of Accounts, Full Papers, Notes and Communications in English.