Sacubitril/valsartan alleviates myocardial infarction-induced inflammation in mice by promoting M2 macrophage polarisation via regulation of PI3K/Akt pathway

IF 2.1 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Acta cardiologica Pub Date : 2024-09-11 DOI:10.1080/00015385.2024.2400401

Nan Jin, Ying Qiu, Kuanxin Zhang, Yulin Fang, Shifang Qu, Lu Zhu, Han Li, Bin Nie

引用次数: 0

Abstract

Macrophage polarisation-mediated inflammation plays a critical role in ventricular remodelling after myocardial infarction (MI). Sacubitril/Valsartan (Sac/Val) is an angiotensin receptor-neprilysin...

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萨库比特利/缬沙坦通过调节 PI3K/Akt 通路促进 M2 巨噬细胞极化，从而减轻小鼠心肌梗死诱发的炎症反应

巨噬细胞极化介导的炎症在心肌梗塞（MI）后心室重塑中起着至关重要的作用。萨库比特利/缬沙坦（Sac/Val）是一种血管紧张素受体-肾素酶抑制剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta cardiologica 医学-心血管系统

CiteScore

2.50

自引率

12.50%

发文量

115

审稿时长

2 months

期刊介绍： Acta Cardiologica is an international journal. It publishes bi-monthly original, peer-reviewed articles on all aspects of cardiovascular disease including observational studies, clinical trials, experimental investigations with clear clinical relevance and tutorials.