Phenome-Wide Association of APOE Alleles in the All of Us Research Program

Abstract

Background Genetic variation in APOE is associated with altered lipid metabolism, as well as cardiovascular and neurodegenerative disease risk. However, prior studies are largely limited to European ancestry populations and differential risk by sex and ancestry has not been widely evaluated. We utilized a phenome-wide association study (PheWAS) approach to explore APOE- associated phenotypes in the All of Us Research Program.