The Successful Use of Upadacitinib as Monotherapy for Hidradenitis Suppurativa and Ulcerative Colitis in the Setting of Refractory Disease

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-09-11 DOI:10.1111/pde.15759

Meryem T. Ok, Paul B. Googe, Christopher J. Sayed, Craig Burkhart, Ajay S. Gulati, Elizabeth L. Nieman

引用次数: 0

Abstract

Hidradenitis suppurativa (HS) and ulcerative colitis (UC) are associated chronic inflammatory conditions with complex disease courses and potential for overlapping therapeutic management. We describe a case of severe pediatric HS and UC that were poorly controlled despite several standard‐of‐care therapies, including infliximab and ustekinumab. Transitioning the patient to upadacitinib monotherapy resulted in clinical improvement of both her UC and HS within 3 months, and she was then able to be weaned off her other systemic therapies. While upadacitinib is not currently FDA‐approved for HS or pediatric UC, this case report shows promise for upadacitinib monotherapy for both of these complex inflammatory disorders.

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奥帕他替尼作为单药疗法成功用于治疗难治性化脓性扁桃体炎和溃疡性结肠炎

化脓性扁桃体炎（HS）和溃疡性结肠炎（UC）是相关的慢性炎症，病程复杂，治疗方法有可能重叠。我们描述了一例严重的小儿化脓性结肠炎和溃疡性结肠炎患者，尽管他们接受了包括英夫利昔单抗和乌司替尼在内的多种标准疗法，但病情控制不佳。将患者转为使用达帕替尼单药治疗后，她的 UC 和 HS 在 3 个月内都得到了临床改善，随后她就可以停用其他系统疗法了。虽然目前达帕替尼尚未获得 FDA 批准用于治疗 HS 或儿科 UC，但这一病例报告显示了达帕替尼单药治疗这两种复杂炎症性疾病的前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.