RH5: rationally-designed malaria vaccine antigen improving efficacy

IF 7 1区医学 Q1 PARASITOLOGY

Trends in parasitology Pub Date : 2024-09-13 DOI:10.1016/j.pt.2024.09.001

Eizo Takashima, Takafumi Tsuboi

引用次数: 0

Abstract

Plasmodium falciparum reticulocyte-binding protein homolog 5 (RH5) is a unique asexual blood-stage malaria vaccine candidate because of its high conservation and essential biological function of binding to basigin on the erythrocyte surface. Recent studies by Barrett et al., Wang et al., and King et al., have brought RH5-based vaccine development a step forward based on a rational antigen design strategy.

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RH5：合理设计疟疾疫苗抗原，提高疗效

恶性疟原虫网织红细胞结合蛋白同源物 5（RH5）是一种独特的无性血期疟疾疫苗候选物，因为它具有与红细胞表面的碱性蛋白结合的高度保守性和基本生物学功能。Barrett 等人、Wang 等人和 King 等人最近的研究基于合理的抗原设计策略，将基于 RH5 的疫苗开发向前推进了一步。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in parasitology 医学-寄生虫学

CiteScore

14.00

自引率

3.10%

发文量

148

审稿时长

6-12 weeks

期刊介绍： Since its inception as Parasitology Today in 1985, Trends in Parasitology has evolved into a highly esteemed review journal of global significance, reflecting the importance of medical and veterinary parasites worldwide. The journal serves as a hub for communication among researchers across all disciplines of parasitology, encompassing endoparasites, ectoparasites, transmission vectors, and susceptible hosts. Each monthly issue of Trends in Parasitology offers authoritative, cutting-edge, and yet accessible review articles, providing a balanced and comprehensive overview, along with opinion pieces offering personal and novel perspectives. Additionally, the journal publishes a variety of short articles designed to inform and stimulate thoughts in a lively and widely-accessible manner. These include Science & Society (discussing the interface between parasitology and the general public), Spotlight (highlighting recently published research articles), Forum (presenting single-point hypotheses), Parasite/Vector of the Month (featuring a modular display of the selected species), Letter (providing responses to recent articles in Trends in Parasitology), and Trendstalk (conducting interviews). Please note that the journal exclusively publishes literature reviews based on published data, with systematic reviews, meta-analysis, and unpublished primary research falling outside our scope.

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