Azole-Substituted Triazole Formation through Organocatalytic Cycloaddition of β-keto Azoles and Aryl Azides

Abstract

A highly efficient metal free regioselective approach for the synthesis of a novel azole substituted triazoles via organocatalytic [3+2] cycloaddition between β-keto azoles and aryl azides at room temperature is reported. The proposed methodology is well tolerated with range of substituents in the β-keto azoles and aryl azides with good to excellent yield (81–94 %) without column chromatography as purification technique under ambient reaction conditions.