{"title":"Tomentediline A: A isoquinoline alkaloids with undescribed carbon skeleton from Corydalis tomentella","authors":"","doi":"10.1016/j.phytochem.2024.114282","DOIUrl":null,"url":null,"abstract":"<div><p>Two undescribed isoquinolines (<strong>1</strong>–<strong>2</strong>), including one undescribed carbon skeleton isoquinoline together with six known ones (<strong>4–9</strong>) as well as an undescribed amide (<strong>3</strong>) and three known ones (<strong>10–12</strong>) were isolated from <em>C. tomentella</em>. Their planar structures and absolute configurations were elucidated by extensive analyses of UV, NMR, HRESIMS, DP4+ statistical analysis and ECD calculations, respectively. Tomentediline A (<strong>1</strong>) is an isoquinoline alkaloid dimer that forms an undescribed carbon carbon bond at the C-13 position of (<em>2H</em>)-protoberberine in a natural product discovered for the first time. Meantime, <strong>1</strong> exerted moderate cytotoxicity against the U251 cell lines, indicating that the undescribed dimer skeleton of isoquinoline compound has the potential for anti-glioma.</p></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":null,"pages":null},"PeriodicalIF":3.2000,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0031942224003194","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Two undescribed isoquinolines (1–2), including one undescribed carbon skeleton isoquinoline together with six known ones (4–9) as well as an undescribed amide (3) and three known ones (10–12) were isolated from C. tomentella. Their planar structures and absolute configurations were elucidated by extensive analyses of UV, NMR, HRESIMS, DP4+ statistical analysis and ECD calculations, respectively. Tomentediline A (1) is an isoquinoline alkaloid dimer that forms an undescribed carbon carbon bond at the C-13 position of (2H)-protoberberine in a natural product discovered for the first time. Meantime, 1 exerted moderate cytotoxicity against the U251 cell lines, indicating that the undescribed dimer skeleton of isoquinoline compound has the potential for anti-glioma.
期刊介绍：
Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
