Global burden and cross-country inequalities in six major immune-mediated inflammatory diseases from 1990 to 2021: A systemic analysis of the Global Burden of Disease Study 2021

IF 9.2 1区 医学 Q1 IMMUNOLOGY
{"title":"Global burden and cross-country inequalities in six major immune-mediated inflammatory diseases from 1990 to 2021: A systemic analysis of the Global Burden of Disease Study 2021","authors":"","doi":"10.1016/j.autrev.2024.103639","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>This study aims to describe the global burden trends of six immune-mediated inflammatory diseases (IMIDs), including asthma, atopic dermatitis (AD), inflammatory bowel disease (IBD), multiple sclerosis (MS), psoriasis and rheumatoid arthritis (RA), from 1990 to 2021, and analyze patterns of cross-country inequalities.</p></div><div><h3>Methods</h3><p>The estimates for the number of disability-adjusted life-years (DALYs) and age-standardized DALYs rates (ASDR), along with the 95 % uncertainty intervals (UI) for asthma, AD, IBD, MS, psoriasis and RA, were obtained from the Global Burden of Diseases Study 2021. The estimated annual percentage change (EAPC) was used to quantify the global burden trends of these six IMIDs from 1990 to 2021. Additionally, slope index of inequality and concentration index were employed to quantify the distributional inequalities in the burden of IMIDs.</p></div><div><h3>Results</h3><p>From 1990 to 2021, the global ASDR of psoriasis (EAPC = 0.23 %, 95 % UI: 0.21 to 0.25) and RA (EAPC = 0.05 %, 95 % UI: 0.01to 0.10) showed an increasing trend, while the global ASDRs of asthma (EAPC = −1.91 %, 95 % UI: −1.98 to −1.84), AD (EAPC = −0.26 %, 95 % UI: −0.27 to −0.26), IBD (EAPC = −0.52 %, 95 % UI: −0.60 to −0.43) and MS (EAPC = −0.39 %, 95 % UI: −0.45 to −0.33) demonstrated declining trends. The cross-country inequality analysis reveals pronounced heterogeneity in the burden of these six IMIDs.</p></div><div><h3>Conclusions</h3><p>The global distribution of the DALYs burden attributable to IMIDs exhibits significant disparities across regions, underscoring an urgent need for innovative and comprehensive management strategies to address this heterogeneous landscape.</p></div>","PeriodicalId":8664,"journal":{"name":"Autoimmunity reviews","volume":null,"pages":null},"PeriodicalIF":9.2000,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Autoimmunity reviews","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1568997224001307","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background

This study aims to describe the global burden trends of six immune-mediated inflammatory diseases (IMIDs), including asthma, atopic dermatitis (AD), inflammatory bowel disease (IBD), multiple sclerosis (MS), psoriasis and rheumatoid arthritis (RA), from 1990 to 2021, and analyze patterns of cross-country inequalities.

Methods

The estimates for the number of disability-adjusted life-years (DALYs) and age-standardized DALYs rates (ASDR), along with the 95 % uncertainty intervals (UI) for asthma, AD, IBD, MS, psoriasis and RA, were obtained from the Global Burden of Diseases Study 2021. The estimated annual percentage change (EAPC) was used to quantify the global burden trends of these six IMIDs from 1990 to 2021. Additionally, slope index of inequality and concentration index were employed to quantify the distributional inequalities in the burden of IMIDs.

Results

From 1990 to 2021, the global ASDR of psoriasis (EAPC = 0.23 %, 95 % UI: 0.21 to 0.25) and RA (EAPC = 0.05 %, 95 % UI: 0.01to 0.10) showed an increasing trend, while the global ASDRs of asthma (EAPC = −1.91 %, 95 % UI: −1.98 to −1.84), AD (EAPC = −0.26 %, 95 % UI: −0.27 to −0.26), IBD (EAPC = −0.52 %, 95 % UI: −0.60 to −0.43) and MS (EAPC = −0.39 %, 95 % UI: −0.45 to −0.33) demonstrated declining trends. The cross-country inequality analysis reveals pronounced heterogeneity in the burden of these six IMIDs.

Conclusions

The global distribution of the DALYs burden attributable to IMIDs exhibits significant disparities across regions, underscoring an urgent need for innovative and comprehensive management strategies to address this heterogeneous landscape.

1990 至 2021 年六种主要免疫介导炎症性疾病的全球负担和跨国不平等:2021 年全球疾病负担研究的系统分析
背景本研究旨在描述六种免疫介导的炎症性疾病(IMIDs)的全球负担趋势,包括哮喘、特应性皮炎(AD)、炎症性肠病(IBD)、多发性硬化症(MS)、银屑病和类风湿性关节炎(RA),从 1990 年到 2021 年,并分析跨国不平等的模式。方法哮喘、注意力缺失症、肠道传染病、多发性硬化症、银屑病和类风湿性关节炎的残疾调整生命年(DALYs)和年龄标准化残疾调整生命年率(ASDR)的估计值以及 95 % 的不确定性区间(UI)均来自《2021 年全球疾病负担研究》。估算的年度百分比变化(EAPC)用于量化这六种 IMID 从 1990 年到 2021 年的全球负担趋势。结果从 1990 年到 2021 年,银屑病(EAPC = 0.23 %,95 % UI:0.21 至 0.25)和 RA(EAPC = 0.05 %,95 % UI:0.01 至 0.10)的全球 ASDR 呈上升趋势。10)呈上升趋势,而哮喘(EAPC = -1.91 %,95 % UI:-1.98 至 -1.84 )、AD(EAPC = -0.26 %,95 % UI:-0.27 至 -0.26)、IBD(EAPC = -0.52 %,95 % UI:-0.60 至 -0.43)和 MS(EAPC = -0.39 %,95 % UI:-0.45 至 -0.33)的全球 ASDR 呈下降趋势。结论IMIDs造成的残疾调整寿命年数负担的全球分布在各地区之间存在显著差异,这表明迫切需要创新和全面的管理策略来应对这种差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Autoimmunity reviews
Autoimmunity reviews 医学-免疫学
CiteScore
24.70
自引率
4.40%
发文量
164
审稿时长
21 days
期刊介绍: Autoimmunity Reviews is a publication that features up-to-date, structured reviews on various topics in the field of autoimmunity. These reviews are written by renowned experts and include demonstrative illustrations and tables. Each article will have a clear "take-home" message for readers. The selection of articles is primarily done by the Editors-in-Chief, based on recommendations from the international Editorial Board. The topics covered in the articles span all areas of autoimmunology, aiming to bridge the gap between basic and clinical sciences. In terms of content, the contributions in basic sciences delve into the pathophysiology and mechanisms of autoimmune disorders, as well as genomics and proteomics. On the other hand, clinical contributions focus on diseases related to autoimmunity, novel therapies, and clinical associations. Autoimmunity Reviews is internationally recognized, and its articles are indexed and abstracted in prestigious databases such as PubMed/Medline, Science Citation Index Expanded, Biosciences Information Services, and Chemical Abstracts.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信