Electrospun nanofibrous membranes meet antibacterial nanomaterials: From preparation strategies to biomedical applications

IF 18 1区医学 Q1 ENGINEERING, BIOMEDICAL

Bioactive Materials Pub Date : 2024-09-11 DOI:10.1016/j.bioactmat.2024.09.003

Shengqiu Chen , Yi Xie , Kui Ma , Zhiwei Wei , Xingwu Ran , Xiaobing Fu , Cuiping Zhang , Changsheng Zhao

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Abstract

Electrospun nanofibrous membranes (eNFMs) have been extensively developed for bio-applications due to their structural and compositional similarity to the natural extracellular matrix. However, the emergence of antibiotic resistance in bacterial infections significantly impedes the further development and applications of eNFMs. The development of antibacterial nanomaterials substantially nourishes the engineering design of antibacterial eNFMs for combating bacterial infections without relying on antibiotics. Herein, a comprehensive review of diverse fabrication techniques for incorporating antibacterial nanomaterials into eNFMs is presented, encompassing an exhaustive introduction to various nanomaterials and their bactericidal mechanisms. Furthermore, the latest achievements and breakthroughs in the application of these antibacterial eNFMs in tissue regenerative therapy, mainly focusing on skin, bone, periodontal and tendon tissues regeneration and repair, are systematically summarized and discussed. In particular, for the treatment of skin infection wounds, we highlight the antibiotic-free antibacterial therapy strategies of antibacterial eNFMs, including (i) single model therapies such as metal ion therapy, chemodynamic therapy, photothermal therapy, and photodynamic therapy; and (ii) multi-model therapies involving arbitrary combinations of these single models. Additionally, the limitations, challenges and future opportunities of antibacterial eNFMs in biomedical applications are also discussed. We anticipate that this comprehensive review will provide novel insights for the design and utilization of antibacterial eNFMs in future research.

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电纺纳米纤维膜与抗菌纳米材料：从制备策略到生物医学应用

电纺纳米纤维膜（eNFMs）因其结构和成分与天然细胞外基质相似，已被广泛开发用于生物应用。然而，细菌感染中出现的抗生素耐药性极大地阻碍了 eNFMs 的进一步开发和应用。抗菌纳米材料的发展极大地促进了抗菌 eNFMs 的工程设计，使其能够在不依赖抗生素的情况下对抗细菌感染。本文全面综述了将抗菌纳米材料融入 eNFMs 的各种制造技术，包括对各种纳米材料及其杀菌机制的详尽介绍。此外，还系统地总结和讨论了这些抗菌 eNFMs 在组织再生疗法中应用的最新成果和突破，主要侧重于皮肤、骨骼、牙周和肌腱组织的再生和修复。特别是在治疗皮肤感染伤口方面，我们重点介绍了抗菌 eNFMs 的无抗生素抗菌治疗策略，包括（i）金属离子疗法、化学动力疗法、光热疗法和光动力疗法等单一模式疗法；以及（ii）涉及这些单一模式任意组合的多模式疗法。此外，还讨论了生物医学应用中抗菌 eNFMs 的局限性、挑战和未来机遇。我们希望这篇全面的综述能为抗菌 eNFMs 在未来研究中的设计和利用提供新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioactive Materials Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

28.00

自引率

6.30%

发文量

436

审稿时长

20 days

期刊介绍： Bioactive Materials is a peer-reviewed research publication that focuses on advancements in bioactive materials. The journal accepts research papers, reviews, and rapid communications in the field of next-generation biomaterials that interact with cells, tissues, and organs in various living organisms. The primary goal of Bioactive Materials is to promote the science and engineering of biomaterials that exhibit adaptiveness to the biological environment. These materials are specifically designed to stimulate or direct appropriate cell and tissue responses or regulate interactions with microorganisms. The journal covers a wide range of bioactive materials, including those that are engineered or designed in terms of their physical form (e.g. particulate, fiber), topology (e.g. porosity, surface roughness), or dimensions (ranging from macro to nano-scales). Contributions are sought from the following categories of bioactive materials: Bioactive metals and alloys Bioactive inorganics: ceramics, glasses, and carbon-based materials Bioactive polymers and gels Bioactive materials derived from natural sources Bioactive composites These materials find applications in human and veterinary medicine, such as implants, tissue engineering scaffolds, cell/drug/gene carriers, as well as imaging and sensing devices.