Exploring the promising role of chitosan delivery systems in breast cancer treatment: A comprehensive review

IF 2.4 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
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Abstract

Breast cancer presents a significant global health challenge, driving the development of novel treatment strategies for therapeutic interventions. Nanotechnology has emerged as a promising avenue for addressing this challenge, with Chitosan (CS) nanoparticles receiving prominence due to their unique characteristics and multitude of potential applications. This review provides a comprehensive overview of the role of Chitosan nanoparticles in breast cancer therapy. The review begins by emphasizing the prevalence and importance of breast cancer as a major health issue, underscoring the necessity for effective treatments. It then delves into the application of Chitosan nanoparticles in breast cancer therapy. One key aspect discussed is their role as carriers for anticancer drugs, enabling targeted delivery and improved cellular uptake. Furthermore, the review explores modified Chitosan nanoparticles and strategies for enhancing their efficacy and specificity in breast cancer treatment. It also examines Chitosan conjugates and hybrids, which offer innovative approaches for combination therapy. Additionally, metal and magnetic Chitosan nanoparticles are discussed spanning their capacity to assist in imaging, hyperthermia, as well as targeted drug delivery. In conclusion, the review summarizes the current research landscape regarding Chitosan nanoparticles for breast cancer therapy and offers insights into future directions. Overall, the review highlights the versatility, potential benefits, and future prospects of Chitosan nanoparticles in combating breast cancer.

Abstract Image

探索壳聚糖给药系统在乳腺癌治疗中的前景:综述
乳腺癌是全球健康面临的重大挑战,推动了新型治疗干预策略的发展。纳米技术已成为应对这一挑战的一条大有可为的途径,壳聚糖(CS)纳米粒子因其独特的特性和多种潜在应用而备受瞩目。本综述全面概述了壳聚糖纳米粒子在乳腺癌治疗中的作用。综述首先强调了乳腺癌作为主要健康问题的普遍性和重要性,强调了有效治疗的必要性。然后深入探讨了壳聚糖纳米粒子在乳腺癌治疗中的应用。其中讨论的一个关键方面是壳聚糖纳米粒子作为抗癌药物载体的作用,可实现靶向给药并提高细胞吸收率。此外,该综述还探讨了改性壳聚糖纳米粒子以及增强其在乳腺癌治疗中的疗效和特异性的策略。报告还探讨了壳聚糖共轭物和混合物,它们为联合治疗提供了创新方法。此外,还讨论了金属和磁性壳聚糖纳米粒子在成像、热疗和靶向给药方面的辅助能力。最后,综述总结了当前壳聚糖纳米粒子用于乳腺癌治疗的研究情况,并对未来的研究方向提出了见解。总之,综述强调了壳聚糖纳米粒子在抗击乳腺癌方面的多功能性、潜在优势和未来前景。
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来源期刊
Carbohydrate Research
Carbohydrate Research 化学-生化与分子生物学
CiteScore
5.00
自引率
3.20%
发文量
183
审稿时长
3.6 weeks
期刊介绍: Carbohydrate Research publishes reports of original research in the following areas of carbohydrate science: action of enzymes, analytical chemistry, biochemistry (biosynthesis, degradation, structural and functional biochemistry, conformation, molecular recognition, enzyme mechanisms, carbohydrate-processing enzymes, including glycosidases and glycosyltransferases), chemical synthesis, isolation of natural products, physicochemical studies, reactions and their mechanisms, the study of structures and stereochemistry, and technological aspects. Papers on polysaccharides should have a "molecular" component; that is a paper on new or modified polysaccharides should include structural information and characterization in addition to the usual studies of rheological properties and the like. A paper on a new, naturally occurring polysaccharide should include structural information, defining monosaccharide components and linkage sequence. Papers devoted wholly or partly to X-ray crystallographic studies, or to computational aspects (molecular mechanics or molecular orbital calculations, simulations via molecular dynamics), will be considered if they meet certain criteria. For computational papers the requirements are that the methods used be specified in sufficient detail to permit replication of the results, and that the conclusions be shown to have relevance to experimental observations - the authors'' own data or data from the literature. Specific directions for the presentation of X-ray data are given below under Results and "discussion".
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