Got bile? Breastmilk bile acids influence norovirus infection

IF 20.6 1区医学 Q1 MICROBIOLOGY

Cell host & microbe Pub Date : 2024-09-11 DOI:10.1016/j.chom.2024.08.001

Joshua J. Baty, Julie K. Pfeiffer

引用次数: 0

Abstract

Breastfeeding provides infection protection for several pathogens but not for noroviruses. Mechanisms explaining this discrepancy have been unclear. In this issue of Cell Host & Microbe, Peiper et al. demonstrate that while breastmilk protects mice from intestinal damage, it promotes neonatal murine norovirus infection due to maternal-derived bile acids.¹

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有胆汁吗？母乳胆汁酸影响诺如病毒感染

母乳喂养对多种病原体的感染有保护作用，但对诺罗病毒却没有保护作用。造成这种差异的机制尚不清楚。在本期《细胞、宿主与amp; 微生物》（Cell Host & Microbe）杂志上，Peiper 等人证明，虽然母乳能保护小鼠免受肠道损伤，但由于母源胆汁酸的作用，母乳能促进新生小鼠感染诺如病毒。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell host & microbe 生物-微生物学

CiteScore

45.10

自引率

1.70%

发文量

201

审稿时长

4-8 weeks

期刊介绍： Cell Host & Microbe is a scientific journal that was launched in March 2007. The journal aims to provide a platform for scientists to exchange ideas and concepts related to the study of microbes and their interaction with host organisms at a molecular, cellular, and immune level. It publishes novel findings on a wide range of microorganisms including bacteria, fungi, parasites, and viruses. The journal focuses on the interface between the microbe and its host, whether the host is a vertebrate, invertebrate, or plant, and whether the microbe is pathogenic, non-pathogenic, or commensal. The integrated study of microbes and their interactions with each other, their host, and the cellular environment they inhabit is a unifying theme of the journal. The published work in Cell Host & Microbe is expected to be of exceptional significance within its field and also of interest to researchers in other areas. In addition to primary research articles, the journal features expert analysis, commentary, and reviews on current topics of interest in the field.