Quick MSA-QoL: A validated, abbreviated health-related quality of life questionnaire for use in Multiple System Atrophy

IF 3.1 3区医学 Q2 CLINICAL NEUROLOGY

Parkinsonism & related disorders Pub Date : 2024-09-06 DOI:10.1016/j.parkreldis.2024.107143

D. Jugnarain, A. Schrag

{"title":"Quick MSA-QoL: A validated, abbreviated health-related quality of life questionnaire for use in Multiple System Atrophy","authors":"D. Jugnarain, A. Schrag","doi":"10.1016/j.parkreldis.2024.107143","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Health-related quality of life is an important patient-reported outcome, which can be assessed using instruments such as the Multiple System Atrophy (MSA) Quality of Life (MSA-QoL) scale. However, at 40-items its length can prove burdensome, particularly to patients with a disease such as MSA. This can contribute to respondent burden and poor-quality response data.</p></div><div><h3>Objective</h3><p>The objective of this study was to develop an abbreviated MSA-QoL scale for use in clinical practise and trials (Quick MSA-QoL).</p></div><div><h3>Methods</h3><p>A single-factor 15-item scale was developed with data from 310 patients with MSA, using exploratory factor analysis (EFA). A separate dataset (n = 279) was used for analysis of psychometric properties and for confirmatory factor analysis.</p></div><div><h3>Results</h3><p>Missing data was minimal, with even distribution of scores and negligible floor/ceiling effects (0/0.4%). Reliability was high (Cronbach alpha 0.870, test-retest reliability 0.950). Good item-total scale correlations were observed (r = 0.402–0.618), and the overall scale correlated well with other validated questionnaires including the original MSA-QoL (r = 0.862). Confirmatory factor analysis demonstrated acceptable model fit indices. Responsiveness data from re-administration of the Quick MSA-QoL 10 months from baseline testing found the overall scale to be sensitive to change.</p></div><div><h3>Conclusions</h3><p>These data suggest that the Quick MSA-QoL is a suitable and efficient scale for use in clinical trials, minimising respondent burden and maintaining data quality.</p></div>","PeriodicalId":19970,"journal":{"name":"Parkinsonism & related disorders","volume":"128 ","pages":"Article 107143"},"PeriodicalIF":3.1000,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1353802024011556/pdfft?md5=7c15fc51c84f9e5fae14d6069dce3388&pid=1-s2.0-S1353802024011556-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Parkinsonism & related disorders","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1353802024011556","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Health-related quality of life is an important patient-reported outcome, which can be assessed using instruments such as the Multiple System Atrophy (MSA) Quality of Life (MSA-QoL) scale. However, at 40-items its length can prove burdensome, particularly to patients with a disease such as MSA. This can contribute to respondent burden and poor-quality response data.

Objective

The objective of this study was to develop an abbreviated MSA-QoL scale for use in clinical practise and trials (Quick MSA-QoL).

Methods

A single-factor 15-item scale was developed with data from 310 patients with MSA, using exploratory factor analysis (EFA). A separate dataset (n = 279) was used for analysis of psychometric properties and for confirmatory factor analysis.

Results

Missing data was minimal, with even distribution of scores and negligible floor/ceiling effects (0/0.4%). Reliability was high (Cronbach alpha 0.870, test-retest reliability 0.950). Good item-total scale correlations were observed (r = 0.402–0.618), and the overall scale correlated well with other validated questionnaires including the original MSA-QoL (r = 0.862). Confirmatory factor analysis demonstrated acceptable model fit indices. Responsiveness data from re-administration of the Quick MSA-QoL 10 months from baseline testing found the overall scale to be sensitive to change.

Conclusions

These data suggest that the Quick MSA-QoL is a suitable and efficient scale for use in clinical trials, minimising respondent burden and maintaining data quality.

查看原文本刊更多论文

快速 MSA-QoL：用于多系统萎缩症的经过验证的简短健康相关生活质量调查问卷

背景与健康相关的生活质量是一项重要的患者报告结果，可通过多系统萎缩（MSA）生活质量量表（MSA-QoL）等工具进行评估。然而，该量表长达 40 个项目，可能会给患者，尤其是患有 MSA 等疾病的患者造成负担。本研究的目的是开发一种简短的 MSA 生活质量量表（Quick MSA-QoL），供临床实践和试验使用。方法采用探索性因子分析 (EFA) 方法，利用 310 名 MSA 患者的数据开发了一种单因子 15 项量表。另一个数据集（n = 279）用于心理测量特性分析和确认性因子分析。结果数据缺失极少，得分分布均匀，下限/上限效应可忽略不计（0/0.4%）。信度很高（Cronbach alpha 0.870，测试-再测信度 0.950）。项目与总量表之间具有良好的相关性（r = 0.402-0.618），总体量表与包括原始 MSA-QoL （r = 0.862）在内的其他经过验证的问卷具有良好的相关性。确认性因素分析表明模型拟合指数可以接受。这些数据表明，快速 MSA-QoL 是一种适用于临床试验的高效量表，可最大程度地减轻受试者的负担并保持数据质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Parkinsonism & related disorders 医学-临床神经学

CiteScore

6.20

自引率

4.90%

发文量

292

审稿时长

39 days

期刊介绍： Parkinsonism & Related Disorders publishes the results of basic and clinical research contributing to the understanding, diagnosis and treatment of all neurodegenerative syndromes in which Parkinsonism, Essential Tremor or related movement disorders may be a feature. Regular features will include: Review Articles, Point of View articles, Full-length Articles, Short Communications, Case Reports and Letter to the Editor.