Nesfatin-1 is a regulator of inflammation with implications during obesity and metabolic syndrome

IF 4.6 2区医学 Q1 BEHAVIORAL SCIENCES

Appetite Pub Date : 2024-09-07 DOI:10.1016/j.appet.2024.107669

Tara L. Steffen, Joshua D. Stafford, Willis K. Samson, Gina L.C. Yosten

引用次数: 0

Abstract

Nesfatin-1, derived from the nucleobindin 2 (NUCB2) precursor, is a potent anorexigenic peptide that was discovered in 2006. Since its identification in the hypothalamus, it has been shown to have wide ranging actions within and outside of the central nervous system. One of these actions is the regulation of inflammation, which could potentially be exploited therapeutically in the context of obesity-associated inflammation in adipose tissue. Here, we review recent advances in our knowledge about the ability of nesfatin-1 to control inflammation by regulating NFκB signaling, which likely attenuates pro-inflammatory cytokine production and inhibits apoptosis.

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Nesfatin-1 是炎症的调节因子，对肥胖症和代谢综合征有影响

Nesfatin-1源自核结合蛋白2（NUCB2）前体，是一种强效厌食肽，于2006年被发现。自从在下丘脑中被发现以来，它已被证明在中枢神经系统内外具有广泛的作用。其中一个作用是调节炎症，这有可能被用于治疗肥胖相关的脂肪组织炎症。在这里，我们回顾了有关内司蛋白-1通过调节NFκB信号来控制炎症的能力的最新进展，这种能力可能会减轻促炎症细胞因子的产生并抑制细胞凋亡。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Appetite 医学-行为科学

CiteScore

9.10

自引率

11.10%

发文量

566

审稿时长

13.4 weeks

期刊介绍： Appetite is an international research journal specializing in cultural, social, psychological, sensory and physiological influences on the selection and intake of foods and drinks. It covers normal and disordered eating and drinking and welcomes studies of both human and non-human animal behaviour toward food. Appetite publishes research reports, reviews and commentaries. Thematic special issues appear regularly. From time to time the journal carries abstracts from professional meetings. Submissions to Appetite are expected to be based primarily on observations directly related to the selection and intake of foods and drinks; papers that are primarily focused on topics such as nutrition or obesity will not be considered unless they specifically make a novel scientific contribution to the understanding of appetite in line with the journal's aims and scope.