Human sperm RNA in male infertility

IF 12.1 1区医学 Q1 UROLOGY & NEPHROLOGY

Nature Reviews Urology Pub Date : 2024-09-10 DOI:10.1038/s41585-024-00920-9

Rossella Cannarella, Andrea Crafa, Roberto Curto, Laura M. Mongioì, Vincenzo Garofalo, Vittorio Cannarella, Rosita A. Condorelli, Sandro La Vignera, Aldo E. Calogero

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Abstract

The function and value of specific sperm RNAs in apparently idiopathic male infertility are currently poorly understood. Whether differences exist in the sperm RNA profile between patients with infertility and fertile men needs clarification. Similarly, the utility of sperm RNAs in predicting successful sperm retrieval and assisted reproductive technique (ART) outcome is unknown. Patients with infertility and fertile individuals seem to have differences in the expression of non-coding RNAs that regulate genes controlling spermatogenesis. Several RNAs seem to influence embryo quality and development. Also, RNA types seem to predict successful sperm retrieval in patients with azoospermia. These findings suggest that sperm RNAs could influence decision-making during the management of patients with infertility. This evidence might help to identify possible therapeutic approaches aimed at modulating the expression of dysregulated genes in patients with infertility. Performing prospective studies with large sample sizes is necessary to investigate cost-effective panels consisting of proven molecular targets to ensure that this evidence can be translated to clinical practice.

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男性不育症中的人类精子 RNA

目前，人们对特定精子 RNA 在明显特发性男性不育症中的功能和价值还知之甚少。不育症患者和育龄男性的精子 RNA 特征是否存在差异需要澄清。同样，精子 RNA 在预测成功取精和辅助生殖技术（ART）结果方面的效用也不得而知。不育症患者和生育能力强的人在调控精子发生基因的非编码 RNA 表达上似乎存在差异。有几种 RNA 似乎会影响胚胎的质量和发育。此外，RNA 类型似乎还能预测无精子症患者能否成功取精。这些发现表明，精子 RNA 可影响不育症患者的治疗决策。这些证据可能有助于确定可能的治疗方法，以调节不育症患者体内失调基因的表达。有必要进行大样本量的前瞻性研究，以调查由已证实的分子靶点组成的成本效益面板，确保这些证据能转化为临床实践。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Urology 医学-泌尿学与肾脏学

CiteScore

12.50

自引率

2.60%

发文量

123

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Urology is part of the Nature Reviews portfolio of journals.Nature Reviews' basic, translational and clinical content is written by internationally renowned basic and clinical academics and researchers. This journal targeted readers in the biological and medical sciences, from the postgraduate level upwards, aiming to be accessible to professionals in any biological or medical discipline. The journal features authoritative In-depth Reviews providing up-to-date information on topics within a field's history and development. Perspectives, News & Views articles, and the Research Highlights section offer topical discussions and opinions, filtering primary research from various medical journals. Covering a wide range of subjects, including andrology, urologic oncology, and imaging, Nature Reviews provides valuable insights for practitioners, researchers, and academics within urology and related fields.